A nurse is reviewing the list of current medications for a client who has a new prescription for nitroglycerin. The nurse should identify that which of the following client medications is contraindicated for use with nitroglycerin?
Sildenafil
Gemfibrozil
Lansoprazole
Diazepam
The Correct Answer is A
Both sildenafil and nitroglycerin are vasodilators and can lead to severe hypotension when used together. Sildenafil acts by inhibiting phosphodiesterase 5 (PDE 5), an enzyme that breaks down cGMP, which regulates blood flow in the penis. The medication also results in the dilation of blood vessels in the lungs, which is beneficial for treating pulmonary arterial hypertension.
B, C, D- No interactions with nitroglycerin
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Related Questions
Correct Answer is D
Explanation
Filgrastim is a medication that stimulates the production of white blood cells (WBCs), particularly neutrophils, which are a type of WBC important for fighting infections. An increase in the WBC count would indicate that filgrastim is effectively stimulating the production of WBCs, which is desirable, especially in clients who are at risk of neutropenia (low WBC count) due to chemotherapy or other factors.
Monitoring potassium levels is important for clients receiving certain medications or experiencing conditions that can affect potassium balance, but it is not specifically related to filgrastim therapy.
BUN is a measure of kidney function and hydration status, but it is not typically monitored to evaluate the effectiveness of filgrastim treatment.
INR is a measure of blood clotting and is primarily monitored in clients receiving anticoagulant therapy, such as warfarin. It is not relevant to filgrastim therapy.
Correct Answer is C
Explanation
Furosemide and amikacin. Furosemide and aminoglycosides are ototoxic and can cause hearing loss. The nurse should monitor for any signs of hearing disturbances such as tinnitus. The other drugs listed in the options have no effect on hearing.
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