A nurse is reviewing the list of current medications for a client who has a new prescription for nitroglycerin. The nurse should identify that which of the following client medications is contraindicated for use with nitroglycerin?
Sildenafil
Gemfibrozil
Lansoprazole
Diazepam
The Correct Answer is A
Both sildenafil and nitroglycerin are vasodilators and can lead to severe hypotension when used together. Sildenafil acts by inhibiting phosphodiesterase 5 (PDE 5), an enzyme that breaks down cGMP, which regulates blood flow in the penis. The medication also results in the dilation of blood vessels in the lungs, which is beneficial for treating pulmonary arterial hypertension.
B, C, D- No interactions with nitroglycerin
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Related Questions
Correct Answer is D
Explanation
metoclopramide is a dopamine antagonist which could interact with central dopamine receptors to cause tardive dyskinesia. The nurse should monitor the client for tardive dyskinesia, a serious movement disorder that can be caused by high-dose metoclopramide. When administering injections, it is generally recommended to inject the medication into the lateral thigh.
A-ACEIS, ARBS cause angioedema and persistent dry cough
B-Corticosteroids or other immunosuppressants increases risk of fungal infections such as oral candidiasis
C-anticoagulants can cause black stools which is a sign of upper GI bleeding.
Correct Answer is B
Explanation
- Theophylline is used in the management of asthma and COPD which present with wheezing and respiratory distress. COPD is characterized by chronic inflammation of the airway and increased mucus secretion leading to obstruction of airflow. Theophylline stimulates the respiratory centers to increase ventilation.
A- No effect on blood pressure C- increases urine output
D-Theophylline is a CNS stimulant
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