A nurse is reviewing a client's peak and trough levels of gentamicin. The peak should be 6 to 8 mcg/mL and the trough should be 0.5 to 1 mcg/mL. The client's peak is10 mcg/mL and his trough is 2.3 mcg/mL. Which of the following clinical manifestations should the nurse expect with these findings? (Select all that apply.)

To calculate the flow rate in gtt/min, the total volume (400 mL) should be divided by the total time in minutes (8 hours x 60 minutes/hour = 480 minutes). This gives the mL/min.

Then, multiply the mL/min by the drop factor (60 gtt/mL) to get the gtt/min. So, the calculation would be (400 mL / 480 min) x 60 gtt/mL = 50 gtt/min.

Therefore, the nurse should set the manual IV infusion to deliver 50 gtt/min.

B. Sharps containers should be replaced when they are 3/4 full to prevent overfilling, which could increase the risk of needlesticks when trying to dispose of sharps. Ensuring sharps containers are not overfilled helps maintain a safe environment by reducing the risk of accidental puncture injuries during disposal.

A. Used razors should be disposed of in puncture-resistant sharps containers, not in regular wastebaskets. Sharps containers are specifically designed to safely contain sharp objects to prevent accidental injuries.

C. Using two hands to recap a needle is unsafe and increases the risk of accidental needlestick injuries. It's important to educate healthcare workers to avoid recapping needles whenever possible.

D. Breaking needles before disposal is unsafe and increases the risk of injury. Needles should be disposed of intact in a puncture-resistant sharps container.