A nurse is providing discharge instructions to a client who has rheumatoid arthritis and a prescription for oral betamethasone. Which of the following statements should the nurse make about how to take this medication?

Choice A reason:

Purple striations: Purple striations, or stretch marks, are more commonly associated with Cushing’s syndrome, which involves excess cortisol production. Addison’s disease, on the other hand, is characterized by insufficient cortisol and aldosterone production.

Choice B reason:

Hirsutism: Hirsutism refers to excessive hair growth in women in areas where hair is normally minimal or absent. It is not typically associated with Addison’s disease. Hirsutism is more commonly linked to conditions involving excess androgens, such as polycystic ovary syndrome (PCOS).

Choice C reason:

Hyperpigmentation: Hyperpigmentation, or darkening of the skin, is a hallmark symptom of Addison’s disease. This occurs due to increased production of melanocyte-stimulating hormone (MSH) as a byproduct of elevated adrenocorticotropic hormone (ACTH) levels. The skin changes are often most noticeable in areas exposed to friction, such as the elbows, knees, and knuckles.

Choice D reason:

Intention tremors: Intention tremors, which occur during purposeful movement, are not typically associated with Addison’s disease. These tremors are more commonly seen in neurological conditions such as multiple sclerosis or cerebellar disorders.

Choice A reason:

Creatinine: Creatinine is a waste product produced by muscles and is filtered out of the blood by the kidneys. Elevated creatinine levels can indicate kidney dysfunction. However, in this scenario, the primary concern is liver damage due to the combination of alcohol and acetaminophen, making AST a more relevant marker.

Choice B reason:

Aspartate aminotransferase (AST): AST is an enzyme found in the liver and heart. Elevated levels of AST can indicate liver damage. Given the client’s high intake of both alcohol and acetaminophen, there is a significant risk of liver damage. Monitoring AST levels can help assess the extent of liver injury.

Choice C reason:

Amylase: Amylase is an enzyme produced by the pancreas and salivary glands that helps in the digestion of carbohydrates. Elevated amylase levels are typically associated with pancreatic disorders, such as pancreatitis. While important, it is not the priority in this case where liver damage is the main concern.

Choice D reason:

Antidiuretic hormone (ADH): ADH is a hormone that helps regulate water balance in the body by controlling the amount of water reabsorbed by the kidneys. Abnormal levels of ADH can indicate issues with fluid balance, but it is not directly related to liver function or the effects of alcohol and acetaminophen.