A nurse is preparing to administer voriconazole 6 mg/kg via intermittent IV bolus to a client who weighs 127 lb. Available is voriconazole 5 mg/mL. How many mL should the nurse administer?
(Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)
The Correct Answer is ["69"]
To calculate the amount of voriconazole to be administered, we can follow these steps:
Convert the client's weight from pounds to kilograms.
Calculate the total amount of voriconazole needed based on the client's weight.
Determine the volume of the medication to be administered based on the concentration of the available solution.
Let's proceed with the calculations:
Converting the client's weight from pounds to kilograms:
Client's weight = 127 lb
1 lb ≈ 0.453592 kg
Client's weight ≈ 127 lb 0.453592 kg/lb ≈ 57.61 kg
Calculating the total amount of voriconazole needed:
Voriconazole dose = 6 mg/kg 57.61 kg ≈ 345.66 mg
Determining the volume of the medication to be administered:
Available voriconazole concentration = 5 mg/mL
Volume to be administered = 345.66 mg / 5 mg/mL ≈ 69.132 mL
Rounding to the nearest whole number, the nurse should administer 69 mL of voriconazole.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A reason: Elimination is the process of removing a drug from the body, usually through the kidneys or the liver. Acute renal failure is a condition where the kidneys suddenly lose their ability to filter waste products and excess fluid from the blood. This can impair the elimination of drugs that are mainly excreted by the kidneys, leading to increased drug levels and potential toxicity. The nurse should monitor the patient's renal function and adjust the dose of drugs that are renally eliminated.
Choice B reason: Metabolism is the process of transforming a drug into one or more metabolites, usually by enzymes in the liver. Acute renal failure does not directly affect the metabolism of drugs, unless it causes liver damage or alters the blood flow to the liver. The nurse should monitor the patient's liver function and the levels of drugs that are metabolized by the liver.
Choice C reason: Distribution is the process of transferring a drug from the blood to the tissues and organs of the body. Acute renal failure can affect the distribution of drugs that are bound to plasma proteins, such as albumin. When the kidneys are damaged, they may leak protein into the urine, causing hypoalbuminemia (low levels of albumin in the blood). This can increase the amount of free or unbound drug in the blood, which may enhance the drug's effect or cause adverse reactions. The nurse should monitor the patient's serum albumin level and the effects of drugs that are highly protein bound.
Choice D reason: Absorption is the process of moving a drug from the site of administration to the bloodstream. Acute renal failure does not directly affect the absorption of drugs, unless it causes changes in the gastrointestinal tract, such as edema, bleeding, or motility disorders. The nurse should monitor the patient's gastrointestinal function and the bioavailability of drugs that are administered orally.
Correct Answer is C
Explanation
Choice A reason: This is incorrect because labetalol is a safe and effective medication for treating hypertension in pregnancy. Labetalol is a beta-blocker that lowers blood pressure by reducing the heart rate and the force of contraction. It does not affect the blood flow to the placenta or the fetus.
Choice B reason: This is incorrect because labetalol is not contraindicated for smokers. However, smoking is a risk factor for cardiovascular disease and should be discouraged by the nurse. Smoking can increase blood pressure, heart rate, and the risk of blood clots.
Choice C reason: This is correct because labetalol is contraindicated for clients with a history of uncontrolled asthma. Labetalol is a non-selective beta-blocker that can block the beta-2 receptors in the lungs and cause bronchoconstriction. This can worsen asthma symptoms and trigger an asthma attack.
Choice D reason: This is incorrect because labetalol is a suitable medication for clients who had a myocardial infarction. Labetalol can prevent further damage to the heart muscle by reducing the oxygen demand and the workload of the heart. It can also prevent arrhythmias and angina.
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