A nurse is preparing to administer diphenhydramine to a client who is to receive a blood transfusion. The nurse should explain that the purpose diphenhydramine is to prevent which of the following manifestations of a transfusion reaction?

A. Family history: Having a family history of peptic ulcers increases the risk of developing the condition, suggesting a genetic predisposition.

B. Blood type A: There is no direct association between blood type A and peptic ulcer disease.

C. Acetaminophen (Tylenol) intake for pain: Acetaminophen is generally considered safe for pain relief and is not a significant risk factor for peptic ulcer disease. However, nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen are known to increase the risk of peptic ulcers.

D. Smoking tobacco: Smoking tobacco is a significant risk factor for peptic ulcer disease. Tobacco use increases stomach acid production, weakens the protective lining of the stomach and duodenum, and impairs the healing of ulcers.

E. Drinking caffeine: While caffeine consumption alone may not directly cause peptic ulcers, excessive intake of caffeinated beverages such as coffee, tea, and soda can aggravate existing ulcers by stimulating stomach acid production and increasing gastric acidity.

A) "The amount of blood pumped by the heart through the circulatory system in 1 minute."
This statement describes cardiac output, which is the volume of blood pumped by the heart per minute, and is not directly related to digestion.

B) "Smooth muscle movement of the GI tract by way of contractions."
This statement describes peristalsis, which is the rhythmic contraction of smooth muscles in the gastrointestinal tract that propels food and waste materials through the digestive system. While peristalsis is an important aspect of digestion, it does not encompass the entire process.

C) "Neutralization by use of bicarbonate from pancreatic and biliary secretions."
This statement refers to the neutralization of acidic chyme from the stomach by bicarbonate ions released from pancreatic and biliary secretions in the duodenum. While this process is a part of digestion, it specifically addresses the regulation of pH rather than the breakdown of food molecules into absorbable forms.

D) "It is the process when food is broken down into molecules that can be absorbed."
This statement accurately describes digestion, which is the process by which complex food molecules are broken down into simpler forms (such as carbohydrates into sugars, proteins into amino acids, and fats into fatty acids and glycerol) that can be absorbed and utilized by the body. Digestion occurs in various stages along the gastrointestinal (GI) tract and involves the action of enzymes, acids, and mechanical processes to facilitate the breakdown of food into absorbable nutrients.