A nurse is preparing to administer amoxicillin 350 mg PO. Available is amoxicillin 250 mg/5 mL. How many mL should the nurse administer? (Round to the nearest whole number.) mL.

Choice A rationale:
While distribution can affect a person’s response to medication, it is not the aspect of genetic makeup most likely to alter this response.
Choice B rationale:
Absorption can affect how a drug is taken up by the body, but it is not the aspect of genetic makeup most likely to alter a person’s response to medication.
Choice C rationale:
Excretion, or how the body eliminates a drug, can affect drug response, but it is not the aspect of genetic makeup most likely to alter this response.
Choice D rationale:
Metabolism, or how the body processes a drug, is the aspect of genetic makeup most likely to alter a person’s response to medication. Genetic differences can lead to variations in drug-metabolizing enzymes, affecting how quickly or slowly drugs are metabolized.

Choice A rationale:
Women experience more problems than men when taking aspirin due to Gastric acidity. Aspirin can cause gastric irritation, and women have been found to have higher gastric acidity than men.
Choice B rationale:
Levels of hepatic enzyme do not specifically cause women to have more problems with aspirin than men. These enzymes are involved in drug metabolism, but their levels do not differ significantly between genders.
Choice C rationale:
Amounts of alcohol dehydrogenase do not cause more problems for women when taking aspirin. This enzyme is involved in alcohol metabolism, not aspirin.
Choice D rationale:
Decreased gastric emptying can increase the risk of gastric irritation from nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin in older adults, but it’s not a gender-specific factor.