A nurse is collecting data from a client who takes several daily medications and states that he wants to ask the provider for a prescription for sildenafil. The nurse knows that sildenafil is contraindicated due to an interaction with which of the following client's medications?
Cefuroxime
Metformin
Isosorbide
Naproxen
The Correct Answer is C
A. There's no documented interaction between cefuroxime and sildenafil. Cefuroxime is an antibiotic, and there are no known significant interactions with sildenafil.
B. There's no documented interaction between metformin and sildenafil. Metformin, an antidiabetic medication, does not interact significantly with sildenafil.
C. Both sildenafil and isosorbide are vasodilators, and concomitant use can result in severe hypotension due to additive effects on blood pressure lowering. Therefore, their combination is contraindicated.
D. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), does not have a significant interaction with sildenafil. They can be safely used together in most cases, although caution may be needed in individuals with cardiovascular risk factors.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
A. While risperidone can cause orthostatic hypotension, which may result in decreased blood pressure, it is not typically associated with elevated blood pressure.
B. Risperidone has been associated with metabolic side effects such as weight gain, dyslipidemia, and increased triglyceride levels, which can contribute to cardiovascular risk.
C. Risperidone is not typically associated with hypoglycemia; instead, it may lead to hyperglycemia or exacerbate existing diabetes.
D. Weight gain is a more common adverse effect of risperidone rather than weight loss.
Monitoring for weight gain is essential due to its association with metabolic syndrome and cardiovascular risk factors.
Correct Answer is B
Explanation
A. Ginger root is not known to reduce the effectiveness of oral contraceptives significantly.
B. St. John's wort is an herbal supplement that can induce the cytochrome P450 enzyme system, leading to increased metabolism of oral contraceptives and potentially reducing their effectiveness. Women taking oral contraceptives should be cautioned against using St. John's wort or advised to use alternative contraceptive methods.
C. Gingko biloba is not known to reduce the effectiveness of oral contraceptives significantly.
D. Glucosamine is not known to reduce the effectiveness of oral contraceptives significantly.
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