A nurse is caring for a client with manifestations of status asthmaticus. Which of the following factors play a role in creating circulatory surge of inflammatory cells and cytokines in this condition? (Select all that apply.)
(Select All that Apply.)

Epithelial cells

OT lymphocytes

Hyperreactivity

Mast cells

Inflammation

Answer and Explanation

Correct Answer : A,D,E

Choice A Reason:

Epithelial cells is correct. Epithelial cells lining the airways play a role in initiating the inflammatory response in asthma by releasing cytokines and other inflammatory mediators. These cells can contribute to the circulatory surge of inflammatory cells and cytokines seen in status asthmaticus.

Choice B Reason:

OT lymphocytes is incorrect. There is no specific cell type known as "OT lymphocytes." It's possible this may refer to T lymphocytes (T cells), which are involved in the immune response in asthma but are not typically associated with a circulatory surge in status asthmaticus.

Choice C Reason:

Hyperreactivity is incorrect. Hyperreactivity refers to the exaggerated response of the airways to various stimuli, leading to bronchoconstriction and inflammation. While hyperreactivity is a characteristic feature of asthma, it does not directly contribute to a circulatory surge of inflammatory cells and cytokines.

Choice D Reason:

Mast cells is correct. Mast cells are key players in the pathophysiology of asthma. They release various inflammatory mediators, including histamine and leukotrienes, which contribute to airway inflammation, bronchoconstriction, and mucus production. Mast cells can participate in the circulatory surge of inflammatory cells and cytokines in status asthmaticus.

Choice E Reason:

Inflammation is correct. Inflammation is a hallmark feature of asthma and plays a central role in the pathogenesis of status asthmaticus. The inflammatory response involves the recruitment and activation of various inflammatory cells, release of cytokines, and other mediators that contribute to airway obstruction and systemic effects.

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Correct Answer is C

Explanation

Choice A Reason:

Air cannot pass freely into the thoracic cavity through a chest wound is incorrect because air can indeed pass freely into the thoracic cavity through the chest wound in an open pneumothorax.

Choice B Reason:

The air is trapped when it enters the cavity is incorrect because the characteristic feature of an open pneumothorax is that air is not trapped; rather, it enters the thoracic cavity with each inhalation and exits with each exhalation through the chest wound.

Choice C Reason:

Air moves in and out of a wound in the chest wall is correct. In an open pneumothorax, also known as a "sucking chest wound," air can freely move in and out of the thoracic cavity through a wound in the chest wall. This occurs due to the creation of a communication pathway between the external environment and the pleural space, typically caused by a penetrating injury to the chest.

Choice D Reason:

There are no audible sounds in an open pneumothorax is incorrect because in an open pneumothorax, there may be audible sounds associated with the movement of air in and out of the wound, such as a sucking or bubbling sound, depending on the size and location of the wound. These sounds can be clinically significant and aid in the diagnosis of an open pneumothorax.

A. Dulaglutide B. Montelukast sodium C. Glatiramer acetate D. Oxybutynin

Correct Answer is D

Explanation

Choice A Reason:

Dulaglutide is inappropriate. Dulaglutide is a medication used to treat type 2 diabetes by improving blood sugar control. It is not indicated for the management of neurogenic bladder or urinary incontinence.

Choice B Reason:

Montelukast sodium is inappropriate. Montelukast sodium is a medication primarily used to treat asthma and allergic rhinitis by blocking leukotrienes, which are inflammatory substances that contribute to asthma and allergy symptoms. It is not indicated for the management of neurogenic bladder or urinary incontinence.

Choice C Reason:

Glatiramer acetate is inappropriate. Glatiramer acetate is a medication used to treat relapsing-remitting multiple sclerosis (MS) by modulating the immune system. It is not indicated for the management of neurogenic bladder or urinary incontinence.

Choice D Reason:

Oxybutynin is appropriate. Oxybutynin is a medication commonly prescribed for the management of neurogenic bladder and urinary incontinence. It belongs to a class of medications called anticholinergics, which work by relaxing the bladder muscles and reducing bladder spasms. Oxybutynin helps control urinary urgency, frequency, and incontinence associated with neurogenic bladder, including spasm-induced incontinence.

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A nurse is caring for a client with manifestations of status asthmaticus. Which of the following factors play a role in creating circulatory surge of inflammatory cells and cytokines in this condition? (Select all that apply.) (Select All that Apply.)

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A nurse is caring for a client with manifestations of status asthmaticus. Which of the following factors play a role in creating circulatory surge of inflammatory cells and cytokines in this condition? (Select all that apply.)
(Select All that Apply.)