A nurse is caring for a client who has degenerative disc disease. Which of the following assessment findings should the nurse understand might develop with this condition?
(Select All that Apply.)

Choice A Reason:

Genetics is correct. There is evidence to suggest that genetics play a role in the development of multiple sclerosis. Although no single gene has been identified as the cause of MS, certain genetic variations have been associated with an increased risk of developing the disease. Having a first-degree relative with MS increases an individual's risk, although the overall genetic contribution to MS susceptibility is thought to be relatively modest.

Choice B Reason:

Environmental factors is correct. Environmental factors are believed to play a significant role in the development of multiple sclerosis, particularly in individuals with a genetic predisposition. Factors such as vitamin D deficiency, smoking, exposure to certain infections (such as Epstein-Barr virus), and geographic location (latitude) have been implicated as potential triggers for MS development.

Choice C Reason:

Upper respiratory infections is incorrect. While infections may trigger exacerbations or relapses in individuals with existing multiple sclerosis, there is limited evidence to suggest that upper respiratory infections contribute directly to the development of MS. However, some research suggests that viral infections, particularly those occurring during childhood or adolescence, may influence the risk of developing MS later in life.

Choice D Reason:

Autoimmune factors is correct. Multiple sclerosis is widely recognized as an autoimmune disease, characterized by immune-mediated inflammation and damage to the central nervous system. In MS, the immune system mistakenly attacks myelin, the protective covering of nerve fibers, leading to demyelination and neurological dysfunction. Autoimmune factors are therefore considered central to the pathogenesis of MS.

Choice E Reason:

Urinary tract infections is incorrect. While urinary tract infections (UTIs) are common in individuals with multiple sclerosis due to bladder dysfunction associated with the disease, there is no direct evidence to suggest that UTIs contribute to the development of MS.

Choice A Reason:

Flying itself is not typically considered a factor that worsens MS manifestations. However, factors related to flying, such as stress, fatigue, changes in routine, and potential exposure to infections, may contribute to symptom exacerbation in some individuals with MS.

Choice B Reason:

Sunbathing is appropriate. Exposure to excessive heat, such as sunbathing or prolonged exposure to hot weather, can lead to temporary worsening of MS symptoms, a phenomenon known as Uhthoff's phenomenon. Increased body temperature can temporarily impair nerve conduction in individuals with MS, resulting in exacerbation of symptoms such as fatigue, weakness, sensory disturbances, and cognitive impairment.

Choice C Reason:

Working in an office is inappropriate. Working in an office environment is not inherently associated with exacerbation of MS manifestations. However, factors such as stress, fatigue, poor ergonomic conditions, and limited mobility during prolonged periods of sitting may contribute to symptom exacerbation in some individuals with MS.

Choice D Reason:

High altitude travel is inappropriate. High altitude travel can exacerbate MS symptoms due to the decreased oxygen levels and potential changes in barometric pressure at high altitudes. Hypoxia (low oxygen levels) at high altitudes may exacerbate fatigue, weakness, and cognitive impairment in individuals with MS. Changes in barometric pressure can also trigger or worsen symptoms such as headaches, sensory disturbances, and balance problems in some individuals with MS.