A nurse is caring for a client who has variant angina and is prescribed verapamil. Which of the following are expected outcomes of this medication? (Select all that apply.)

Warfarin (Coumadin) is a blood thinner that prevents blood clots from forming or growing larger.

It is used to treat or prevent deep vein thrombosis (DVT), a condition in which a blood clot forms in a vein deep in the body, usually in the legs.

It can also prevent pulmonary embolism (PE), a condition in which a blood clot breaks off and travels to the lungs, blocking blood flow and causing breathing problems.

Patients taking warfarin should follow these instructions:

• Avoid foods that are high in vitamin K.

Vitamin K is needed for the production of some clotting factors in the liver.

Warfarin blocks the action of vitamin K, and thus reduces the clotting ability of the blood.

However, if the intake of vitamin K varies significantly from day to day, it can affect the stability of the warfarin effect.Foods that are high in vitamin K include green leafy vegetables, such as spinach, kale, broccoli, cabbage, and lettuce, as well as some vegetable oils, such as soybean and canola.Patients should not avoid these foods completely, but they should keep their intake consistent and inform their doctor or pharmacist if they make any changes to their diet.

• Report any unusual bleeding to healthcare provider.

Warfarin can increase the risk of bleeding, especially if the dose is too high or if it interacts with other medications or supplements.Patients should notify their doctor or seek emergency care if they have any signs of bleeding, such as bruising, red or black stools, blood in the urine, coughing up blood, vomiting blood, nosebleeds, heavy menstrual bleeding, headaches, dizziness, weakness, or swelling.They should also inform their doctor of any other medications or supplements they are taking, including over-the-counter products and herbal remedies.

• Use an electric razor when shaving.

Warfarin can make the skin more prone to bleeding from minor cuts or injuries.

Patients should use an electric razor when shaving to reduce the risk of nicking themselves and causing bleeding.They should also use a soft toothbrush and avoid flossing if it causes bleeding.They should wear gloves when handling sharp objects or working in the garden.

Choice B and E are wrong because:

• Take aspirin for pain relief.

Aspirin is a medication that also prevents blood clots by inhibiting platelets, which are cells that stick together to form clots.Taking aspirin with warfarin can increase the risk of bleeding significantly and is not recommended unless prescribed by a doctor for a specific reason.Patients should avoid taking aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen or naproxen, for pain relief unless advised by their doctor.They should also check the labels of any over-the-counter medications or supplements they use and avoid those that contain aspirin or NSAIDs.

• Wear shoes that fit well and avoid tight clothing.

This instruction is not related to warfarin therapy and does not affect its efficacy or safety.

However, it may be a general advice for patients with DVT to prevent further complications or discomfort.Wearing shoes that fit well and avoiding tight clothing can help improve blood circulation in the legs and prevent swelling or pain.Patients with DVT should also elevate their legs when possible and wear compression stockings if prescribed by their doctor.

Alteplase is a fibrinolytic agent that dissolves blood clots and restores blood flow.However, it also increases the risk of bleeding from any site, such as the nose, gums, injection sites, or internal organs.Therefore, the nurse should monitor the client for signs of bleeding, such as bruising, hematuria, hematemesis, melena, or decreased hemoglobin and hematocrit levels.

Choice A is wrong because hypotension is not a common adverse effect of alteplase.Hypotension may occur due to blood loss from bleeding or other causes, such as dehydration, sepsis, or cardiac dysfunction.

Choice C is wrong because dysrhythmias are not a common adverse effect of alteplase.Dysrhythmias may occur due to pulmonary embolism itself, which can cause hypoxia, acidosis, and increased pulmonary artery pressure.

Choice D is wrong because nausea is not a common adverse effect of alteplase.Nausea may occur due to other factors, such as anxiety, pain, or medications.

Choice E is wrong because fever is not a common adverse effect of alteplase.Fever may occur due to infection, inflammation, or other causes.