A nurse is caring for a client who has tuberculosis and is about to start taking pyrazinamide.
The nurse should identify that the client needs which of the following tests while taking this medication therapy?

Choice A rationale:

Taking hydrochlorothiazide on an empty stomach is not a requirement for this medication. Hydrochlorothiazide is a diuretic used to treat conditions like hypertension and edema. It can be taken with or without food, and food may help reduce stomach upset for some individuals.

Choice B rationale:

Muscle weakness is an adverse effect of hydrochlorothiazide. Therefore, it is not an expected outcome. Hydrochlorothiazide is a thiazide diuretic, and one of its common side effects is potassium loss through increased urine output. This can lead to muscle weakness and cramping. The nurse should educate the client about the signs and symptoms of low potassium and the importance of including potassium-rich foods in their diet.

Choice C rationale:

Increasing daily intake of foods high in potassium is essential information to include in the teaching for a client taking hydrochlorothiazide. Thiazide diuretics like hydrochlorothiazide can cause potassium depletion, which may result in adverse effects like muscle weakness, cramping, and cardiac dysrhythmias. Therefore, advising the client to consume potassium-rich foods, such as bananas, oranges, and potatoes, can help counteract the potassium loss associated with the medication.

Choice D rationale:

Taking the medication at bedtime is not a specific requirement for hydrochlorothiazide. Thiazide diuretics can be taken at various times of the day, depending on the client's preferences and when they are most compliant with their medication regimen. The timing of administration should be consistent to maintain the medication's effectiveness.

Choice A rationale:
A client who takes glyburide for type 2 diabetes mellitus is not at significant risk for developing digoxin toxicity. Glyburide is an antidiabetic medication and does not interact directly with digoxin.

Choice B rationale: Furosemide, a loop diuretic, can cause electrolyte imbalances such as hypokalemia (normal potassium levels: 3.5 to 5.0 mEq/L) and hypomagnesemia (normal magnesium levels: 1.7 to 2.2 mg/dL). These imbalances increase the sensitivity to digoxin and the risk of toxicity. Digoxin toxicity is associated with symptoms like nausea, vomiting, and arrhythmias. Furosemide's impact on electrolytes makes it a significant risk factor for digoxin toxicity.

Choice C rationale: Cimetidine, a histamine H2 receptor antagonist, can inhibit the metabolism of certain drugs by affecting liver enzymes. However, it does not significantly alter digoxin levels or increase the risk of toxicity. Normal liver enzyme levels include ALT (7 to 56 U/L) and AST (10 to 40 U/L). While cimetidine may interact with other medications, its effect on digoxin is minimal.

Choice D rationale:
A client who takes azelastine for allergic rhinitis is not at significant risk for developing digoxin toxicity. Azelastine is an antihistamine and does not interact directly with digoxin.