A nurse is caring for a client who has Graves' disease. The nurse understands that this condition is caused by what type of hypersensitivity? (Select all that apply.)

Choice A reason:

Type I hypersensitivity is not involved in RA, as it does not involve IgE antibodies or mast cells.

Choice B reason:

Type II hypersensitivity is not involved in RA, as it does not involve IgG or IgM antibodies or target cells.2

Choice C reason:

RA is caused by type III hypersensitivity, which involves the formation and deposition of immune complexes in the synovial membranes of the joints. This triggers complement activation, inflammation, and tissue damage.

Choice D reason:

Type IV hypersensitivity is not involved in RA, as it does not involve cytotoxic T cells or helper T cells.

Choice A reason:

Type I hypersensitivity is not involved in Graves' disease, as it does not involve IgE antibodies or mast cells.

Choice B reason:

Type II hypersensitivity is involved in Graves' disease, as it involves IgG antibodies that bind to the thyroid-stimulating hormone (TSH) receptors on the thyroid gland and stimulate the production of thyroid hormones. This leads to hyperthyroidism and manifestations such as goiter, exophthalmos, tachycardia, weight loss, or tremors.

Choice C reason:

Type III hypersensitivity is not involved in Graves' disease, as it does not involve immune complexes or complement activation.

Choice D reason:

Type IV hypersensitivity is not involved in Graves' disease, as it does not involve cytotoxic T cells or helper T cells.

Choice E reason:

Type V hypersensitivity is also involved in Graves' disease, as it involves the stimulation of target cells by antibodies that act as agonists for cell surface receptors. This leads to an increased function of the target organ or tissue.