A nurse is caring for a client who has Graves' disease. The nurse understands that this condition is caused by what type of hypersensitivity? (Select all that apply.)

Choice A reason:

Type I hypersensitivity is not involved in Graves' disease, as it does not involve IgE antibodies or mast cells.

Choice B reason:

Type II hypersensitivity is involved in Graves' disease, as it involves IgG antibodies that bind to the thyroid-stimulating hormone (TSH) receptors on the thyroid gland and stimulate the production of thyroid hormones. This leads to hyperthyroidism and manifestations such as goiter, exophthalmos, tachycardia, weight loss, or tremors.

Choice C reason:

Type III hypersensitivity is not involved in Graves' disease, as it does not involve immune complexes or complement activation.

Choice D reason:

Type IV hypersensitivity is not involved in Graves' disease, as it does not involve cytotoxic T cells or helper T cells.

Choice E reason:

Type V hypersensitivity is also involved in Graves' disease, as it involves the stimulation of target cells by antibodies that act as agonists for cell surface receptors. This leads to an increased function of the target organ or tissue.

Choice A reason:

Bacteria are microorganisms that have a cell wall composed of peptidoglycan and a cell membrane composed of phospholipids. They can be classified by their shape (cocci or bacilli), their Gram stain (positive or negative), or their oxygen requirement (aerobic or anaerobic).

Choice B reason:

Viruses are microorganisms that have a nucleic acid core (DNA or RNA) surrounded by a protein coat (capsid) and sometimes an envelope derived from the host cell membrane. They can only replicate inside living cells and cause various diseases such as influenza, herpes, hepatitis, or AIDS.

Choice C reason:

Fungi are microorganisms that have a cell wall composed of chitin and a cell membrane composed of ergosterol. They can exist as yeasts or molds depending on the environmental conditions. Candida albicans is an example of fungi that can cause infections such as thrush, vaginitis, or systemic candidiasis.

Choice D reason:

Parasites are microorganisms that live on or in another organism (host) and derive nutrients from it. They can be classified by their size (protozoa or helminths) or their mode of transmission (vector-borne or direct contact). They can cause infections such as malaria, giardiasis, or schistosomiasis.