A nurse is caring for a client who has diabetes insipidus and is receiving desmopressin by intermittent IV bolus. Which of the following manifestations should indicate to the nurse a therapeutic response to the medication?

Choice A Reason:
Weight gain of 0.7 kg (1.5 lb) in 24 hours is not recommendable. While sudden weight gain can indicate fluid retention, it is not a direct contraindication for administering digoxin. However, it might indicate worsening heart failure, which needs attention, but it doesn't specifically necessitate withholding digoxin.
Choice B Reason:
Urinary output 30 mL/hr is not recommendable. A low urinary output might indicate decreased kidney perfusion or renal issues. While monitoring urinary output is important, it is not a direct reason to withhold digoxin unless it's coupled with severe renal impairment or an acute kidney injury.
For a client receiving digoxin, certain findings would warrant withholding the medication due to potential complications. Among the options provided:
Choice C Reason:
Pulse rate 56/min is the correct recommendation. A low pulse rate (bradycardia), especially below 60 beats per minute, is a reason to withhold digoxin. Digoxin can further decrease the heart rate, potentially leading to excessive bradycardia or heart block. The nurse should hold the medication and consult with the healthcare provider to determine the appropriate action.
Choice D Reason:
BP 160/90 mm Hg is not recommendable. Elevated blood pressure alone is not a direct contraindication for administering digoxin to a patient with heart failure. Digoxin is not primarily used for controlling blood pressure; its use is more focused on managing heart rate and contractility in heart failure patients.

Choice A Reason:
Oral is incorrect. Epoetin alfa is not typically administered orally because it would be broken down by digestive enzymes and not absorbed effectively from the gastrointestinal tract.
Choice B Reason:
Intravenous is correct. Epoetin alfa is a medication used to stimulate red blood cell production and is commonly administered intravenously. This route allows for rapid and efficient absorption of the medication into the bloodstream, enabling it to exert its effects effectively.
Choice C Reason:
Inhalation is incorrect. Inhalation is not a route used for epoetin alfa. This medication is intended for systemic effects rather than local effects in the respiratory system.
Choice D Reason:
Transdermal is incorrect. Transdermal administration involves absorption through the skin and is not suitable for epoetin alfa, which needs rapid and direct access to the bloodstream for its action on red blood cell production.