A nurse is caring for a client who has diabetes insipidus and is receiving desmopressin by intermittent IV bolus. Which of the following manifestations should indicate to the nurse a therapeutic response to the medication?

Choice A Reason:
INR (International Normalized Ratio) is incorrect. INR is a measurement used to monitor the effects of anticoagulants like warfarin. It assesses the blood's ability to clot. Filgrastim does not directly affect INR levels, so monitoring INR would not provide information about the effectiveness of filgrastim in stimulating white blood cell production.
Choice B Reason:
BUN (Blood Urea Nitrogen) is incorrect. BUN levels primarily indicate kidney function and hydration status. They are not directly influenced by filgrastim treatment. Monitoring BUN is essential for assessing kidney function but does not reflect the effectiveness of filgrastim therapy in increasing white blood cell counts.
Choice C Reason:
WBC count is correct. Filgrastim is a medication that stimulates the production of white blood cells (WBCs), particularly neutrophils. Therefore, the key laboratory value to monitor for assessing the effectiveness of filgrastim therapy is the WBC count. An increase in the WBC count, particularly in the neutrophil count, signifies the intended therapeutic effect of filgrastim in boosting the immune system's response by increasing the production of these infection-fighting cells.
Choice D Reason:
Potassium level is incorrect. Potassium levels are crucial for heart and muscle function. While certain medications might affect potassium levels, filgrastim's primary action is on stimulating white blood cell production and does not directly impact potassium levels. Monitoring potassium levels is essential for overall health but does not specifically indicate the effectiveness of filgrastim treatment.

Choice A Reason:
"I should notify my provider if my stools turn black." This is the appropriate statement. Ferrous gluconate is an iron supplement commonly prescribed to treat or prevent iron deficiency anemia. When taking iron supplements, it's common for stools to become darker or even black in color. This change in stool color is due to the iron and is generally harmless. However, it's essential to inform the healthcare provider about this change because it can also indicate bleeding in the gastrointestinal tract, which requires evaluation.
Choice B Reason:
Taking an antacid with iron supplements can interfere with iron absorption. Antacids may decrease the absorption of iron in the stomach, so it's not recommended to take them together.
Choice C Reason:
While staying upright after taking certain medications can help prevent esophageal irritation or reflux, it's not specifically required with ferrous gluconate.
Choice D Reason:
Taking iron supplements with milk is also not recommended as milk and calcium-containing products can inhibit the absorption of iron. It's generally best to take iron supplements on an empty stomach or with vitamin C to enhance absorption, unless otherwise instructed by the healthcare provider.