A nurse is assessing a client who is receiving a dose of IV amphotericin B. Which of the following findings should indicate to the nurse that the client is experiencing an acute infusion reaction?

A. Prior episode of kidney stones: A history of kidney stones is not a contraindication to prednisone therapy. However, it may require monitoring due to potential fluid and electrolyte imbalances associated with corticosteroid use.
B. Taking levothyroxine orally: Taking levothyroxine orally is not a contraindication to prednisone therapy. However, concurrent use of corticosteroids and levothyroxine may require dosage adjustments of both medications due to potential interactions.
C. Has a systemic fungal infection: Corticosteroids like prednisone can suppress the immune system, increasing the risk of fungal infections and worsening existing fungal infections.
Therefore, the presence of a systemic fungal infection is a contraindication to corticosteroid therapy.
D. History of asthma: Asthma is not a contraindication to prednisone therapy. In fact, prednisone is commonly used as a treatment for asthma exacerbations. However, caution may be needed in individuals with asthma to avoid exacerbating symptoms or complications.

A. Laryngospasm: Laryngospasm is not a commonly associated adverse effect of alteplase administration. It is more commonly associated with airway irritants or allergic reactions.
B. Polycythemia: Polycythemia, or an abnormally high red blood cell count, is not a typical adverse effect of alteplase administration. Alteplase is a thrombolytic agent used to dissolve blood clots and is not associated with increasing red blood cell production.

C. Hemorrhage: Hemorrhage, or bleeding, is the most significant adverse effect associated with alteplase administration. Alteplase works by promoting fibrinolysis and can increase the risk of bleeding, including intracranial hemorrhage, particularly in the context of thrombolytic therapy for stroke.
D. Steatorrhea: Steatorrhea, or fatty stools, is not a commonly associated adverse effect of alteplase administration. It is more commonly associated with malabsorption disorders or pancreatic insufficiency.