A nurse in the Medical-Surgical unit is caring for a client who has had an allogeneic hematopoietic stem-cell transplant. Which of the following infection-control precautions should the nurse use while caring for this client?

Choice A rationale:

A macular rash on the chest and back is not indicative of a paradoxical drug reaction to lorazepam, a benzodiazepine. Paradoxical reactions involve unexpected and opposite responses to a medication, such as increased agitation and excitement instead of the intended calming effect. A rash is not consistent with this type of reaction.

Choice B rationale:

Increased appetite is not associated with a paradoxical drug reaction to lorazepam. Paradoxical reactions involve behavioral and physiological responses that are contrary to the expected effects of the medication. Increased appetite does not fit this pattern.

Choice C rationale:

Drowsiness and mild sedation are the intended effects of lorazepam, a benzodiazepine. Paradoxical reactions are characterized by unexpected and opposite responses. Drowsiness and mild sedation align with the expected pharmacological actions of benzodiazepines, making this choice incorrect for a paradoxical reaction.

Choice D rationale:

Increased agitation and insomnia are indicative of a paradoxical drug reaction to lorazepam. Benzodiazepines like lorazepam are central nervous system depressants and are commonly used to treat anxiety and promote sedation. However, in some cases, paradoxical reactions can occur, leading to increased agitation, excitement, and even insomnia. These reactions are thought to be more common in children and older adults. This choice is correct because it aligns with the characteristics of a paradoxical reaction.

Choice A rationale:

Veracity refers to truthfulness and honesty in communication between the healthcare provider and the client. It involves providing accurate information and not deceiving the client. Discontinuing the experimental medication due to kidney failure demonstrates a commitment to the truth, but the primary ethical principle demonstrated here is nonmaleficence.

Choice B rationale:

Autonomy refers to respecting the client's right to make their own decisions about their healthcare. In this scenario, the medication was discontinued due to evidence of harm to the client's health. This action prioritizes the client's well-being over their autonomy to continue the treatment.

Choice C rationale:

Nonmaleficence, or the principle of "do no harm," is demonstrated in this scenario. The experimental medication was discontinued because it was causing rapidly advancing kidney failure. The healthcare provider's decision to stop the treatment is an example of prioritizing the client's safety and well-being by preventing further harm.

Choice D rationale:

Fidelity refers to being loyal, keeping promises, and maintaining trust in the nurse-client relationship. While this principle is important, it doesn't directly apply to the situation described, where the focus is on the ethical responsibility to prevent harm.