A fearful patient has an increased heart rate and blood pressure. The nurse suspects increased activity of which neurotransmitter?

Choice A reason: GABA, an inhibitory neurotransmitter, reduces neuronal activity, not enhances cognitive functions like memory. Memory improvement is associated with cholinergic or glutamatergic systems, not GABA, making this choice incorrect for the expected effect of GABA potentiation.

Choice B reason: Fewer visual hallucinations are associated with antipsychotics affecting dopamine, not GABA. GABA’s inhibitory effects calm the brain but do not directly target psychotic symptoms like hallucinations, making this choice incorrect for the medication’s effect.

Choice C reason: GABA potentiation, as with benzodiazepines, enhances inhibitory effects, reducing neuronal excitability and calming the central nervous system. This directly alleviates anxiety, a primary therapeutic effect, aligning with GABA’s role in anxiety disorders, making this the correct choice.

Choice D reason: Increased alertness is contrary to GABA’s inhibitory effects, which promote sedation. Stimulants, not GABAergic drugs, enhance alertness, making this choice incorrect, as GABA potentiation leads to calming, not stimulating, effects on the brain.

Choice A reason: Clozapine, an antipsychotic, primarily causes agranulocytosis and metabolic issues, not fluid or electrolyte imbalances. Its effects on the central nervous system and bone marrow do not directly disrupt electrolyte homeostasis, making this choice incorrect for this concern.

Choice B reason: Lithium, a mood stabilizer, affects renal function, impairing sodium and water reabsorption, leading to potential hyponatremia or dehydration. This requires close monitoring of electrolytes, as imbalances can cause toxicity, making this the correct choice for heightened alertness.

Choice C reason: Fluoxetine, an SSRI, primarily affects serotonin levels, with minimal impact on fluid or electrolyte balance. Side effects like nausea do not significantly disrupt electrolytes, making this choice incorrect compared to lithium’s known renal effects.

Choice D reason: Venlafaxine, an SNRI, influences serotonin and norepinephrine but does not significantly affect fluid or electrolyte balance. Its side effects, like hypertension, are unrelated to electrolyte homeostasis, making this choice incorrect for this specific concern.