A client with peptic ulcer disease receives a new prescription for cimetidine. Which statement provided by the client requires additional instruction by the nurse?

Choice A reason: This is not the most important adverse effect for the nurse to report. Nausea is a common side effect of metoclopramide, which is a prokinetic and antiemetic drug that stimulates the motility of the upper GI tract and blocks the dopamine receptors in the chemoreceptor trigger zone. Nausea may be mild or moderate, and it may subside with time or dose adjustment. The nurse should monitor the client's nausea and provide supportive measures, such as fluids, crackers, or ginger, but it is not a priority.

Choice B reason: This is the most important adverse effect for the nurse to report. Involuntary movements, or extrapyramidal symptoms, are a serious and potentially irreversible side effect of metoclopramide, which can occur due to the blockade of the dopamine receptors in the basal ganglia. Involuntary movements can include dystonia, akathisia, parkinsonism, or tardive dyskinesia, and they can affect the face, neck, limbs, or trunk. The nurse should assess the client for any signs of involuntary movements and notify the healthcare provider immediately. The nurse should also prepare to administer an anticholinergic drug, such as benztropine, to counteract the effects of metoclopramide.

Choice C reason: This is not the most important adverse effect for the nurse to report. Unusual irritability is a rare and mild side effect of metoclopramide, which may be related to the central nervous system effects of the drug. Unusual irritability may manifest as restlessness, anxiety, or agitation, and it may resolve with time or dose adjustment. The nurse should monitor the client's mood and behavior and provide reassurance and comfort, but it is not a priority.

Choice D reason: This is not the most important adverse effect for the nurse to report. Diarrhea is a rare and mild side effect of metoclopramide, which may be related to the increased motility of the GI tract. Diarrhea may be transient or self-limiting, and it may be managed with fluids, electrolytes, or antidiarrheal drugs. The nurse should monitor the client's stool frequency and consistency and provide hydration and hygiene, but it is not a priority.

Choice A reason: Diabetic ketoacidosis is a complication of diabetes that occurs when the body produces high levels of ketones due to lack of insulin. Glucagon is not indicated for this condition, as it would increase the blood glucose level even more. The nurse should instruct the client and family to monitor the blood glucose and ketone levels, administer insulin as prescribed, and seek medical attention if the condition worsens.

Choice B reason: Glucagon is not used to prevent hyperglycemia, which is a high blood glucose level. Glucagon is a hormone that raises the blood glucose level by stimulating the breakdown of glycogen in the liver. The nurse should instruct the client and family to prevent hyperglycemia by following a balanced diet, taking insulin as prescribed, and exercising regularly.

Choice C reason: Glucagon is not used when the client is unable to eat during sick days, unless the client has signs of hypoglycemia, which is a low blood glucose level. Glucagon is used as a last resort when the client is unconscious or unable to swallow. The nurse should instruct the client and family to follow the sick day rules, which include monitoring the blood glucose and urine ketone levels, taking insulin as prescribed, drinking fluids, and eating small amounts of carbohydrates.

Choice D reason: Glucagon is used when the client has signs of severe hypoglycemia, such as confusion, seizures, or loss of consciousness. Glucagon is injected subcutaneously or intramuscularly by a family member or a caregiver to raise the blood glucose level quickly. The nurse should instruct the client and family to recognize the signs of hypoglycemia, treat mild to moderate hypoglycemia with oral glucose, and call 911 after administering glucagon.