A client with peptic ulcer disease receives a new prescription for cimetidine. Which statement provided by the client requires additional instruction by the nurse?

Choice A reason: This is not the most important adverse effect for the nurse to report. Nausea is a common side effect of metoclopramide, which is a prokinetic and antiemetic drug that stimulates the motility of the upper GI tract and blocks the dopamine receptors in the chemoreceptor trigger zone. Nausea may be mild or moderate, and it may subside with time or dose adjustment. The nurse should monitor the client's nausea and provide supportive measures, such as fluids, crackers, or ginger, but it is not a priority.

Choice B reason: This is the most important adverse effect for the nurse to report. Involuntary movements, or extrapyramidal symptoms, are a serious and potentially irreversible side effect of metoclopramide, which can occur due to the blockade of the dopamine receptors in the basal ganglia. Involuntary movements can include dystonia, akathisia, parkinsonism, or tardive dyskinesia, and they can affect the face, neck, limbs, or trunk. The nurse should assess the client for any signs of involuntary movements and notify the healthcare provider immediately. The nurse should also prepare to administer an anticholinergic drug, such as benztropine, to counteract the effects of metoclopramide.

Choice C reason: This is not the most important adverse effect for the nurse to report. Unusual irritability is a rare and mild side effect of metoclopramide, which may be related to the central nervous system effects of the drug. Unusual irritability may manifest as restlessness, anxiety, or agitation, and it may resolve with time or dose adjustment. The nurse should monitor the client's mood and behavior and provide reassurance and comfort, but it is not a priority.

Choice D reason: This is not the most important adverse effect for the nurse to report. Diarrhea is a rare and mild side effect of metoclopramide, which may be related to the increased motility of the GI tract. Diarrhea may be transient or self-limiting, and it may be managed with fluids, electrolytes, or antidiarrheal drugs. The nurse should monitor the client's stool frequency and consistency and provide hydration and hygiene, but it is not a priority.

Choice A reason: Employed as a construction worker is not the most important assessment finding for the nurse to address. Although the client's occupation may expose them to moist and warm environments that can promote fungal growth, it is not directly related to the administration of terbinafine HCL. The nurse should advise the client to wear breathable shoes and socks and keep the feet dry and clean, but it is not a priority.

Choice B reason: Reported history of alcoholism is the most important assessment finding for the nurse to address. Terbinafine HCL can cause hepatotoxicity, especially in clients with pre-existing liver disease or who consume alcohol regularly. The nurse should assess the client's liver function tests and alcohol intake before starting the medication and inform the prescriber accordingly. The nurse should also monitor the client for signs and symptoms of liver damage, such as jaundice, abdominal pain, nausea, or fatigue.

Choice C reason: White blood cell count of 8,500/mm3 (8.5 x 10^9/L) is not the most important assessment finding for the nurse to address. This value is within the normal reference range of 5,000 to 10,000/mm3 (5 to 10 x 10^9/L) and does not indicate any infection or inflammation. The nurse should check the client's baseline blood counts before starting the medication, but it is not a priority.

Choice D reason: Toenails appear thick and yellow is not the most important assessment finding for the nurse to address. This is a typical manifestation of a fungal toenail infection, which is the indication for terbinafine HCL. The nurse should expect the toenails to improve in appearance and texture after the completion of the treatment, which may take several weeks or months. The nurse should educate the client about the expected outcomes and adherence to the medication regimen, but it is not a priority.