A client on a medical-surgical unit has been diagnosed with Guillain-Barre Syndrome. The nurse understands that in addition to supportive care, which treatment can be used within the first 2 weeks of symptom onset?

Plasmapheresis

Riluzole

Anticholinesterase agents

Acyclovir

Answer and Explanation

The Correct Answer is A

A.   Plasmapheresis, also known as plasma exchange, is a treatment where blood plasma containing harmful antibodies is removed from the blood and replaced with donor plasma or albumin. This procedure is effective in reducing the severity and duration of symptoms in GBS by removing the antibodies that attack the peripheral nerves. Plasmapheresis is typically recommended within the first 2 weeks of symptom onset to maximize its benefits.
B.   Riluzole is a medication that modulates glutamate neurotransmission and is primarily used in the treatment of amyotrophic lateral sclerosis (ALS). While some studies have explored its potential use in GBS, its efficacy in GBS treatment remains uncertain and it is not considered a standard treatment.
C.   Anticholinesterase agents, such as pyridostigmine, are used in conditions characterized by neuromuscular junction dysfunction, such as myasthenia gravis. However, in GBS, where the primary pathology is the demyelination of peripheral nerves rather than neuromuscular junction dysfunction, anticholinesterase agents are not effective and can potentially worsen symptoms.
D.   Acyclovir is an antiviral medication primarily used to treat infections caused by herpesviruses, including herpes simplex virus (HSV) and varicella-zoster virus (VZV). It has no role in the treatment of GBS because GBS is not caused by viral infections.

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Correct Answer is C

Explanation

A. Medicare does cover individuals under 65 years old who have end-stage renal disease (ESRD) and meet certain criteria.
B. There are programs that allow individuals with both Medicare and low income to qualify for Medicaid, which can help cover additional healthcare costs that Medicare may not fully cover.
C. While Medicare does provide significant coverage for healthcare services, it is not entirely free of out- of-pocket costs. Medicare Part A typically covers hospital stays, skilled nursing facility care, hospice, and some home health care services with no premiums for most people.
D. Medicare is indeed federally-funded health insurance primarily for individuals aged 65 and older. It also covers certain younger individuals with disabilities and those with ESRD.

A. Petechiae on the oral mucosa. B. Hemoglobin of 14 g/dL. C. Bleeding of the gums after oral care. D. Pain and swelling in one leg.

Correct Answer is D

Explanation

A. Petechiae are tiny, pinpoint, red or purple spots on the skin or mucous membranes, caused by bleeding under the skin. While petechiae can indicate bleeding, they are not specific to HIT and can occur due to various reasons, including low platelet count or coagulation disorders. They do not necessarily indicate thrombotic complications associated with HIT.
B. This hemoglobin level is within the normal range for adults and does not directly correlate with HIT. However, it is important to monitor hemoglobin levels in patients with HIT due to the risk of bleeding and thrombosis.
C. Bleeding gums can occur due to various reasons, including gum disease or thrombocytopenia (low platelet count). In HIT, the concern is not just bleeding but also the paradoxical risk of thrombosis despite low platelet counts. Bleeding from mucosal surfaces can indicate underlying thrombocytopenia but does not specifically highlight the thrombotic risk of HIT.
D. This symptom is concerning for deep vein thrombosis (DVT), which is a thrombotic complication associated with HIT. HIT predisposes patients to thrombosis due to the formation of antibodies against

platelet factor 4/heparin complexes, leading to platelet activation and clot formation. DVT is a serious complication that requires immediate intervention to prevent pulmonary embolism (PE).

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A client on a medical-surgical unit has been diagnosed with Guillain-Barre Syndrome. The nurse understands that in addition to supportive care, which treatment can be used within the first 2 weeks of symptom onset?

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