A client is receiving IV vancomycin and the nurse plans to draw blood for a peak and trough to determine the serum level of the medication. Which collection times provide the best determination of these levels?

Immediately after completion of the IV dose and 30 minutes before the next administration of the medication.

One hour after completion of the IV dose and one hour before the next administration of the medication.

Two hours after completion of the IV dose and two hours before the next administration of the medication.

Thirty minutes into the administration of the IV dose and 30 minutes before the next administration of the medication.

Answer and Explanation

The Correct Answer is A

A. Immediately after completion of the IV dose and 30 minutes before the next administration of the medication: This timing is correct for monitoring vancomycin levels. The peak level is typically measured immediately after the completion of the infusion (though peak levels are less commonly required for vancomycin), and the trough level is measured just before the next dose is due, 30 minutes before administration. This approach helps in evaluating the medication's efficacy and safety.
B. One hour after completion of the IV dose and one hour before the next administration of the medication: This timing is not ideal. The peak level for vancomycin is usually measured immediately after the dose rather than one hour later. Trough levels are measured closer to the next dose, typically 30 minutes before the next dose.
C. Two hours after completion of the IV dose and two hours before the next administration of the medication: Measuring levels two hours after the dose completion is too late for a peak level. The trough level should be measured closer to the next dose, generally 30 minutes before the next administration.
D. Thirty minutes into the administration of the IV dose and 30 minutes before the next administration of the medication: Measuring the level 30 minutes into the infusion is not appropriate for peak levels, which are typically measured.

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Correct Answer is C

Explanation

A) Determine if the client is taking the medication before meals: While the timing of medication relative to meals can affect absorption, this action assumes a specific problem without first clarifying the client's concerns. It's important to understand the nature of the client's issue before assessing medication administration.
B) Ask if his morning voiding is dark colored: Dark-colored urine may be a side effect of some medications, but this is a less direct approach to understanding why the client feels the medication is not working. It does not directly address the effectiveness of the medication.
C) Explore what the client means by the drug not working: This is the most appropriate initial intervention. Understanding the client's perception and specific concerns about the medication's effectiveness will guide further actions, such as assessing medication adherence, side effects, or the need for a medication adjustment.

D) Evaluate the client for signs of dyskinesia: While assessing for dyskinesia is important, it is more of a specific follow-up step. The priority is to understand the client's concerns about the medication's overall effectiveness before focusing on specific side effects.

A. Takes metformin hydrochloride for type 2 diabetes mellitus. B. Metal hip prosthesis was placed twenty years ago. C. Report of client's sobriety for the last five years. D. CT scan that was performed six months earlier.

Correct Answer is A

Explanation

A) Takes metformin hydrochloride for type 2 diabetes mellitus: Metformin can interact with the contrast dye used in CT scans, particularly in patients with impaired renal function. The contrast dye can affect kidney function, potentially leading to lactic acidosis in patients taking metformin. It is important to follow up on this history and possibly temporarily discontinue metformin and monitor kidney function before and after the procedure.

B) Metal hip prosthesis was placed twenty years ago: A metal hip prosthesis does not typically affect the CT scan with contrast, though it may affect the imaging technique or quality. This history usually does not require follow-up related to the contrast use.
C) Report of client's sobriety for the last five years: Sobriety does not directly impact the use of contrast dye in a CT scan. This information is relevant for overall health but not specifically for the use of contrast.
D) CT scan that was performed six months earlier: The timing of a previous CT scan is not a contraindication for a new scan with contrast. Follow-up on the history of a prior scan may be relevant for comparison but does not specifically impact the use of contrast dye.

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A client is receiving IV vancomycin and the nurse plans to draw blood for a peak and trough to determine the serum level of the medication. Which collection times provide the best determination of these levels?

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