Which phase of pharmacokinetics involves the movement of a drug from its site of administration to the bloodstream?
Distribution
Metabolism
Excretion
Absorption
The Correct Answer is D
Choice A reason: Distribution is not the correct term to describe the movement of a drug from its site of administration to the bloodstream. Distribution is the process by which a drug moves from the bloodstream to the tissues and organs of the body. Distribution depends on factors such as blood flow, tissue permeability, plasma protein binding, and tissue binding. Distribution occurs after the drug has been absorbed into the bloodstream, and it determines how much drug reaches the site of action.
Choice B reason: Metabolism is not the correct term to describe the movement of a drug from its site of administration to the bloodstream. Metabolism is the process by which a drug is chemically transformed in the body, usually by enzymes in the liver or other tissues. Metabolism can affect the activity, duration, and elimination of a drug. Metabolism occurs after the drug has been absorbed into the bloodstream, and it can occur before or after the drug reaches the site of action.
Choice C reason: Excretion is not the correct term to describe the movement of a drug from its site of administration to the bloodstream. Excretion is the process by which a drug or its metabolites are eliminated from the body. Excretion can occur through various routes, such as urine, feces, sweat, or breath. Excretion occurs after the drug has been absorbed into the bloodstream, and it can occur before or after the drug reaches the site of action.
Choice D reason: Absorption is the correct term to describe the movement of a drug from its site of administration to the bloodstream. Absorption is the process by which a drug enters the bloodstream from the site of administration. Absorption depends on factors such as the route of administration, the dose, the formulation, and the bioavailability of the drug. Absorption is the first step of pharmacokinetics, and it determines how much and how fast a drug reaches the bloodstream and the site of action.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A reason: This is incorrect. Distributing the doses evenly throughout the day may increase the risk of daytime sedation and impair the client's ability to perform daily activities. Diphenhydramine is a sedating antihistamine that causes drowsiness and reduces alertness.
Choice B reason: This is correct. Taking most of the daily dose at bedtime may minimize daytime sedation and help the client sleep better at night. Diphenhydramine is often used as a short-term treatment for insomnia.
Choice C reason: This is incorrect. Taking the medication with meals does not affect the sedative effect of diphenhydramine. It may only reduce the risk of stomach upset, which is not a common side effect of diphenhydramine.
Choice D reason: This is incorrect. Gradually decreasing the dose once tolerance to the effect is reached may not be advisable, as it may reduce the effectiveness of the medication for relieving pruritus. Diphenhydramine is an antihistamine that blocks the action of histamine, a chemical that causes itching and inflammation in allergic reactions.
Correct Answer is ["A","D"]
Explanation
Choice A reason: This is correct. Dry mouth is a common side effect of anticholinergic drugs. It occurs because anticholinergic drugs block the action of acetylcholine, a neurotransmitter that stimulates the secretion of saliva and other fluids in the body. Dry mouth can cause discomfort, bad breath, and increased risk of dental problems¹.
Choice B reason: This is incorrect. Constricted bronchioles are not a side effect of anticholinergic drugs. In fact, anticholinergic drugs can cause the opposite effect: dilated bronchioles. This is because anticholinergic drugs block the action of acetylcholine, a neurotransmitter that causes the smooth muscles of the airways to contract. Dilated bronchioles can improve breathing and reduce wheezing in people with respiratory disorders, such as asthma or COPD.
Choice C reason: This is incorrect. Increased heart rate is not a side effect of anticholinergic drugs. In fact, anticholinergic drugs can cause the opposite effect: decreased heart rate. This is because anticholinergic drugs block the action of acetylcholine, a neurotransmitter that slows down the heart rate and lowers the blood pressure. Decreased heart rate can be beneficial for people with certain heart conditions, such as atrial fibrillation or tachycardia.
Choice D reason: This is correct. Dilated pupils are a common side effect of anticholinergic drugs. It occurs because anticholinergic drugs block the action of acetylcholine, a neurotransmitter that controls the muscles of the iris, which regulate the size of the pupils. Dilated pupils can cause blurred vision, sensitivity to light, and difficulty focusing.
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