Which pathophysiologic events contribute to renal failure associated with tumor lysis syndrome?

Metabolic acidosis.

Elevated white blood cell count.

Crystallization of uric acid in the renal tubules.

Hypocalcemia.

Answer and Explanation

The Correct Answer is C

Choice A rationale
Metabolic acidosis can occur in renal failure but is not directly linked to tumor lysis syndrome.
Choice B rationale
Elevated white blood cell count is not a primary contributor to renal failure in tumor lysis syndrome.
Choice C rationale
Crystallization of uric acid in the renal tubules can obstruct urine flow and cause acute renal failure, which is a direct pathophysiologic event in tumor lysis syndrome.
Choice D rationale
Hypocalcemia is a consequence of tumor lysis syndrome but does not directly cause renal failure.

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Correct Answer is C

Explanation

Choice A rationale
Examining the client for hepatomegaly can be part of a broader assessment but does not directly address the fatigue related to chemotherapy, particularly cisplatin, which is known to cause bone marrow suppression.
Choice B rationale
Assessing for a hypersensitivity reaction is important during chemotherapy, but it does not specifically address the issue of fatigue, which is often related to blood cell counts.
Choice C rationale
Checking the results of the client's most recent CBC (complete blood count) is crucial because cisplatin can cause anemia, leukopenia, and thrombocytopenia, all of which can lead to significant fatigue.
Choice D rationale
Evaluating for hypercalcemia is not typically associated with cisplatin treatment; it is more relevant in malignancies associated with bone metastasis or overproduction of parathyroid hormone-related protein.

A. The client has an increased risk for bleeding. B. The client should receive an erythropoiesis stimulating agent. C. The client has an increased risk of infection. D. The client should receive a diet with increased protein.

Correct Answer is C

Explanation

Choice A rationale
The client's complete blood count does not specifically indicate an increased risk for bleeding. Platelet levels would need to be evaluated for bleeding risk.
Choice B rationale
Erythropoiesis stimulating agents are used for anemia but are not indicated based on the provided CBC.
Choice C rationale
The client is at increased risk of infection due to low white blood cell count (leukopenia), which indicates immunosuppression.
Choice D rationale
While a high-protein diet is beneficial during cancer treatment, the CBC results highlight an infection risk as the primary concern.

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Which pathophysiologic events contribute to renal failure associated with tumor lysis syndrome?

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Naxlex Comprehensive Predictor Exams

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