Which of the following responses indicate that the nurse understands the first-pass effect?
Medication routes that are affected by the first-pass effect include intravenous, intramuscular, and intradermal.
Enteric-coated tablets and capsules are affected by the first-pass effect except a pharmacologic effect.
The first-pass effect is when the liver activates all medications on their first pass through the liver.
Enteral medications may need a higher dose due to the first-pass effect.
The Correct Answer is D
Choice A rationale
Intravenous, intramuscular, and intradermal routes bypass the first-pass effect as they do not pass through the liver first.
Choice B rationale
Enteric-coated tablets and capsules are designed to bypass the stomach and dissolve in the intestines, reducing the first-pass effect.
Choice C rationale
The first-pass effect involves the liver metabolizing and inactivating a portion of the medication on its first pass through the liver.
Choice D rationale
Enteral medications, which pass through the digestive system, may require higher doses due to the first-pass effect where the liver metabolizes the medication before it reaches systemic circulation. .
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A rationale
Gemfibrozil is used to reduce elevated plasma triglycerides (VLDL) and increase HDL levels, which helps in managing hyperlipidemia.
Choice B rationale
This choice is incorrect as gemfibrozil does not reduce HDL but rather increases it while reducing plasma triglycerides (VLDL).
Choice C rationale
Gemfibrozil is not indicated for the treatment of hypertension; it is used for lipid disorders.
Choice D rationale
Gemfibrozil is not used for the treatment of deep vein thrombosis (DVT); it is specifically used to manage lipid levels.
Correct Answer is B
Explanation
Choice A rationale
Metformin is an oral diabetes medication used to treat type 2 diabetes by improving the body's response to insulin.
Choice B rationale
Levodopa/Carbidopa is the standard treatment for Parkinson's disease. Levodopa is converted to dopamine in the brain, which helps improve movement symptoms.
Choice C rationale
Insulin is used to control blood sugar levels in diabetes mellitus, not Parkinson's disease.
Choice D rationale
Cefepime is an antibiotic used to treat bacterial infections, not Parkinson's disease.
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