Which of the following responses indicate that the nurse understands the first-pass effect?
Medication routes that are affected by the first-pass effect include intravenous, intramuscular, and intradermal.
Enteric-coated tablets and capsules are affected by the first-pass effect except a pharmacologic effect.
The first-pass effect is when the liver activates all medications on their first pass through the liver.
Enteral medications may need a higher dose due to the first-pass effect.
The Correct Answer is D
Choice A rationale
Intravenous, intramuscular, and intradermal routes bypass the first-pass effect as they do not pass through the liver first.
Choice B rationale
Enteric-coated tablets and capsules are designed to bypass the stomach and dissolve in the intestines, reducing the first-pass effect.
Choice C rationale
The first-pass effect involves the liver metabolizing and inactivating a portion of the medication on its first pass through the liver.
Choice D rationale
Enteral medications, which pass through the digestive system, may require higher doses due to the first-pass effect where the liver metabolizes the medication before it reaches systemic circulation. .
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A rationale
Aspirin is an antipyretic and analgesic, effective in reducing fever and relieving mild to moderate pain by inhibiting cyclooxygenase enzymes.
Choice B rationale
Aspirin is not used to lower blood pressure; antihypertensive drugs are prescribed for that purpose.
Choice C rationale
Aspirin does not treat bacterial infections; antibiotics are used to eliminate bacterial pathogens.
Choice D rationale
Aspirin does not cure viral infections; antiviral medications are required to treat such conditions. .
Correct Answer is []
Explanation
Condition: Post-operative pain.
2 actions:
Administer acetaminophen (Tylenol) for mild pain,
Apply a warm compress to the surgical site.
2 parameters:
Pain level on a 0-10 scale,
Surgical site appearance.
Rationale for correct condition: Post-operative pain is expected after surgery and the client reports mild pain (2 out of 10). Managing pain is crucial for recovery and mobility. Mild pain indicates the need for non-opioid analgesics. Pain management enhances comfort and healing. Addressing pain prevents complications.
Rationale for actions: Administering acetaminophen targets mild pain effectively. It is appropriate for the reported pain level. Warm compresses can soothe soreness and reduce pain without medication. Encourages blood flow and healing. Encouraging ambulation prevents DVT but is not pain-focused. Monitoring for infection is important but not the priority for mild pain. Ondansetron treats nausea, not pain.
Rationale for parameters: Pain level on a 0-10 scale assesses pain management effectiveness. Monitoring pain ensures appropriate interventions. Surgical site appearance checks for complications affecting pain, like infection. Respiratory rate is stable and less relevant. Oxygen saturation is normal, unrelated to pain. Urine output monitors hydration, not pain.
Rationale for incorrect conditions: Post-operative nausea and vomiting is not reported. Surgical site infection would show signs like redness or fever. DVT focuses on circulation, not pain.
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