Which of the following responses indicate that the nurse understands the first-pass effect?
Medication routes that are affected by the first-pass effect include intravenous, intramuscular, and intradermal.
Enteric-coated tablets and capsules are affected by the first-pass effect except a pharmacologic effect.
The first-pass effect is when the liver activates all medications on their first pass through the liver.
Enteral medications may need a higher dose due to the first-pass effect.
The Correct Answer is D
Choice A rationale
Intravenous, intramuscular, and intradermal routes bypass the first-pass effect as they do not pass through the liver first.
Choice B rationale
Enteric-coated tablets and capsules are designed to bypass the stomach and dissolve in the intestines, reducing the first-pass effect.
Choice C rationale
The first-pass effect involves the liver metabolizing and inactivating a portion of the medication on its first pass through the liver.
Choice D rationale
Enteral medications, which pass through the digestive system, may require higher doses due to the first-pass effect where the liver metabolizes the medication before it reaches systemic circulation. .
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A rationale
Dextromethorphan is not used for asthma. Asthma treatment typically involves bronchodilators and anti-inflammatory medications.
Choice B rationale
Dextromethorphan is an antitussive used to suppress coughing. It acts on the cough center in the brain to reduce the urge to cough.
Choice C rationale
This medication is not used for pain reduction. Pain management usually involves analgesics or anti-inflammatory drugs.
Choice D rationale
Dextromethorphan is not indicated for allergic rhinitis. Allergic rhinitis treatments typically include antihistamines or nasal corticosteroids.
Correct Answer is B
Explanation
Choice A rationale
Insulin is a medication used to manage blood sugar levels in clients with diabetes. It is not appropriate for the management of deep vein thrombosis (DVT) as it has no anticoagulant properties.
Choice B rationale
Warfarin (Coumadin) is an oral anticoagulant commonly prescribed for the long-term management of DVT. It is suitable for clients who are unable to self-administer injections, making it a practical option for discharge.
Choice C rationale
Heparin is an anticoagulant that is typically administered via injection or IV. For clients unable to self-inject at home, it is not the best choice for managing DVT after discharge.
Choice D rationale
Enoxaparin (Lovenox) is a low-molecular-weight heparin that is also administered via injection. For clients unable to perform self-injections, this medication would not be the most appropriate option for home management of DVT.
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