Which medication would be considered a first-line medication therapy for generalized anxiety disorder (GAD)?

Choice A reason: Active suicidality, linked to severe serotonin deficits, requires inpatient hospitalization for constant monitoring to ensure safety. Partial hospitalization is insufficient for acute risk, as it lacks 24-hour supervision, making this patient inappropriate for this less intensive care setting.

Choice B reason: Agoraphobia and panic episodes, driven by norepinephrine surges, benefit from partial hospitalization’s structured psychoeducation and therapy. Relaxation techniques reduce amygdala hyperactivity, supporting outpatient management with daily support, making this patient suitable for partial hospitalization’s intensive, non-residential treatment.

Choice C reason: Stable lithium levels indicate controlled bipolar disorder, not requiring partial hospitalization. Regular follow-up manages neurotransmitter balance, suitable for outpatient care. Partial hospitalization is for active symptoms, not stable patients, making this an incorrect referral choice.

Choice D reason: Alcohol use concerns suggest outpatient substance abuse programs, not partial hospitalization. While dopamine reward pathways are involved, partial hospitalization targets acute psychiatric symptoms, not substance issues alone, making this patient unsuitable for this level of care.

Choice A reason: Flooding involves intense, immediate exposure to the feared stimulus, like elevators, overwhelming amygdala-driven fear responses. This contrasts with gradual exposure, which calms norepinephrine surges incrementally. Flooding is less controlled and riskier, making it incorrect for the described gradual relaxation technique.

Choice B reason: Systematic desensitization pairs gradual exposure to a fear, like elevators, with relaxation to reduce amygdala hyperactivity and norepinephrine-driven panic. This counterconditions fear responses, promoting calm neural pathways, aligning with the described technique and making it the correct choice for this therapeutic approach.

Choice C reason: Combination therapy involves multiple modalities, like medication and psychotherapy, not specifically gradual exposure with relaxation. The described technique targets phobia-specific amygdala responses, not a broad approach, making combination therapy too vague and incorrect for this targeted intervention.

Choice D reason: Cognitive restructuring modifies thought patterns, not exposure-based fear responses. While it addresses distorted beliefs, the described technique uses relaxation with gradual exposure to reduce norepinephrine-driven panic, not cognitive reframing, making this incorrect for the specific therapeutic method described.