Which factor is responsible for the hypertrophy of the myocardium associated with hypertension
Acetylcholine
Adducin
Angiotensin II
Insulin resistance
The Correct Answer is C
Hypertension, or high blood pressure, is a major risk factor for the development of left ventricular hypertrophy (LVH), which is characterized by thickening of the myocardium (heart muscle). LVH occurs in response to increased afterload (the resistance the heart has to pump against), which is a common feature of hypertension.
Angiotensin II, a hormone that is activated in response to hypertension, is a major mediator of LVH in this setting. Angiotensin II causes vasoconstriction (narrowing of blood vessels) and promotes the retention of salt and water, which increases blood volume and pressure. Additionally, angiotensin II stimulates the proliferation of cardiac myocytes (heart muscle cells) and the synthesis of extracellular matrix proteins, leading to hypertrophy and fibrosis of the myocardium.
Other factors that may contribute to LVH in hypertension include increased sympathetic nervous system activity, oxidative stress, and inflammation. However, angiotensin II is considered a key mediator of this process, and drugs that block the renin-angiotensin-aldosterone system (RAAS), such as angiotensinconverting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), are often used to treat hypertension and reduce the risk of LVH and other cardiovascular complications.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
The left ventricle is responsible for pumping oxygenated blood out of the heart and into systemic circulation, which requires generating enough pressure to overcome the resistance of the systemic blood vessels. Therefore, the left ventricle has thicker and more muscular walls than the right ventricle and can generate higher pressures during contraction. In contrast, the right ventricle pumps deoxygenated blood to the lungs, which have lower resistance compared to the systemic circulation, and therefore do not need to generate as high pressures.
Correct Answer is D
Explanation
Hemoptysis is the coughing up of blood or bloody secretions from the respiratory tract. It is a sign of a serious condition and should be reported immediately to a healthcare provider. In this case, the patient's cold and cough may have led to irritation and inflammation of the respiratory tract, resulting in hemoptysis.
- Hematemesis: This is the vomiting of blood from the upper gastrointestinal tract, which usually appears bright red or dark brown in color.
- Cyanosis: This is a bluish discoloration of the skin and mucous membranes caused by the presence of deoxygenated hemoglobin in the blood.
- Rhinitis: This is the inflammation of the nasal mucosa, often causing a runny nose, nasal congestion, and sneezing.
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