Which change occurs first, making patients susceptible to coronary artery disease?

Formation of thrombus in the coronary artery.

Formation of fibrous plaque in the endothelium.

Reduction of blood flow through the coronary arteries.

Development of fatty streaks in the smooth muscles of the endothelium.

Answer and Explanation

The Correct Answer is D

Choice A rationale:

Thrombus formation is a later stage event in coronary artery disease (CAD) and occurs after the development of fatty streaks. Thrombus formation usually happens due to the rupture of atherosclerotic plaques, leading to platelet aggregation and clot formation.

Choice B rationale:

Formation of fibrous plaque in the endothelium is a progression that occurs after the initial development of fatty streaks. Fibrous plaques are formed as a response to the inflammation caused by fatty deposits. They are more stable than fatty streaks but can still lead to narrowing of the arteries.

Choice C rationale:

Reduction of blood flow through the coronary arteries is a consequence of atherosclerosis, which occurs after the initial development of fatty streaks. As the fatty deposits accumulate, they narrow the arteries, leading to reduced blood flow. However, this is not the initial change that makes patients susceptible to CAD.

Choice D rationale:

Development of fatty streaks in the smooth muscles of the endothelium is the initial change that occurs in the development of atherosclerosis, making patients susceptible to coronary artery disease. Fatty streaks are composed of lipid-laden macrophages and smooth muscle cells. Over time, these fatty streaks can progress into fibrous plaques and eventually lead to complications such as thrombus formation and reduced blood flow.

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Correct Answer is B

Explanation

Choice A rationale:

Hemophilia is a hereditary disorder caused by a deficiency of specific clotting factors, and it is indeed hereditary in nature. This statement is incorrect.

Choice B rationale:

Hemophilia is a bleeding disorder where the blood does not clot properly. Replacement therapy, which involves infusing clotting factor concentrates, is a standard treatment for hemophilia. This statement is correct.

Choice C rationale:

Hemophilia is an X-linked recessive genetic disorder, not dominant. Males are more commonly affected because they have only one X chromosome, and if it carries the defective gene, they will have hemophilia. Females have two X chromosomes, and if one X chromosome carries the defective gene, the other X chromosome can compensate, making them carriers but not typically affected.

Choice D rationale:

Hemophilia A is the most common form of hemophilia, not hemophilia B.

A. Serotonin. B. Platelet factor III. C. Von Willebrand factor. D. Adenosine diphosphate.

Correct Answer is C

Explanation

Choice A rationale:

Serotonin is a neurotransmitter that plays a role in mood regulation, sleep, and other functions in the body. It is not a component that forms an adhesive bridge between platelets and vascular subendothelial structures in the clotting process.

Choice B rationale:

Platelet factor III is not a component that forms an adhesive bridge between platelets and vascular subendothelial structures in the clotting process. Platelet factor III is not widely recognized in the context of clotting; it is more commonly referred to as tissue factor and is involved in the extrinsic pathway of coagulation.

Choice C rationale:

Von Willebrand factor (VWF) is a protein that plays a crucial role in hemostasis. It forms an adhesive bridge between platelets and vascular subendothelial structures, particularly at sites of vascular injury. VWF helps platelets adhere to the injured vessel wall, leading to the formation of a stable blood clot. This process is essential for preventing excessive bleeding. A deficiency or dysfunction in VWF can lead to von Willebrand disease, a bleeding disorder characterized by prolonged bleeding times.

Choice D rationale:

Adenosine diphosphate (ADP) is a molecule released by platelets when they are activated. ADP helps in the aggregation of platelets, but it does not directly form an adhesive bridge between platelets and vascular subendothelial structures.

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Which change occurs first, making patients susceptible to coronary artery disease?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

Which statement is true regarding hemophilia?

Correct Answer is B

Explanation

Which component forms an adhesive bridge between platelets and vascular subendothelial structures in the clotting process?

Correct Answer is C

Explanation

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