Which antibiotics are classified as concentration-dependent antimicrobials?

Ciprofloxacin

Imipenem

Penicillin V

Metronidazole

Gentamicin.

Answer and Explanation

The Correct Answer is E

Gentamicin is an example of a concentration-dependent antimicrobial, which means that it achieves increasing bacterial kill with increasing levels of drug. The peak concentration and the area under the concentration curve (AUC) determine the efficacy of these antibiotics. Other examples of concentration-dependent antimicrobials include fluoroquinolones, daptomycin, aminoglycosides, and amphotericin

Choice A is wrong because ciprofloxacin is a fluoroquinolone, which is also a concentration-dependent antimicrobial.

Choice B is wrong because imipenem is a carbapenem, which is a type of beta-lactam antibiotic. Beta-lactams are time-dependent antimicrobials, which means that their bactericidal activity depends on the duration of the effective concentration.

Choice C is wrong because penicillin V is another type of beta-lactam antibiotic, which is also a time-dependent antimicrobial.

Choice D is wrong because metronidazole is a bactericidal agent that has both time- and concentration-dependent properties. However, it is not classified as a concentration-dependent antimicrobial according to the AMEG categorization of antibiotics in the European Union.

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Correct Answer is C

Explanation

Ceftriaxone belongs to the third-generation of cephalosporins.Third-generation cephalosporins have greater activity than the second-generation cephalosporins against certain gram-negative bacteria, such as Streptococcus pneumoniae.They are also more resistant to beta-lactamases, enzymes that can inactivate some cephalosporins.

Choice A is wrong because first-generation cephalosporins have less activity against gram-negative bacteria and are more susceptible to beta-lactamases.

Choice B is wrong because second-generation cephalosporins have less activity against Streptococcus pneumoniae than third-generation cephalosporins, and are also less resistant to beta-lactamases.

Choice D is wrong because fourth-generation cephalosporins have a broader spectrum of activity against gram-negative bacteria, including some that are resistant to third-generation cephalosporins, but they are not more effective against Streptococcus pneumoniae.

A. Elevated serum creatinine level B. Decreased serum potassium level C. Increased serum glucose level D. Decreased white blood cell count.

Correct Answer is A

Explanation

This is because itraconazole can cause renal impairment and decreased urine output as an adverse effect.A normal serum creatinine level is 0.6 to 1.2 mg/dL for males and 0.5 to 1.1 mg/dL for females.

Choice B is wrong because decreased serum potassium level is not an adverse effect of itraconazole.Itraconazole can cause hypokalemia, which is a low level of potassium in the blood, but this is usually due to fluid retention and heart failure caused by the drug.A normal serum potassium level is 3.5 to 5.0 mEq/L.

Choice C is wrong because increased serum glucose level is not an adverse effect of itraconazole.Itraconazole can cause hyperglycemia, which is a high level of glucose in the blood, but this is usually due to diabetes mellitus or steroid use in patients taking the drug.A normal serum glucose level is 70 to 100 mg/dL.

Choice D is wrong because decreased white blood cell count is not an adverse effect of itraconazole.Itraconazole can cause leukopenia, which is a low level of white blood cells in the blood, but this is usually due to bone marrow suppression or infection in patients taking the drug.A normal white blood cell count is 4,500 to 11,000 cells/mm3.

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Which antibiotics are classified as concentration-dependent antimicrobials?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is preparing to administer ceftriaxone (Rocephin) to a client who has pneumonia caused by Streptococcus pneumoniae. The nurse should recognize that ceftriaxone belongs to which generation of cephalosporins?

Correct Answer is C

Explanation

A nurse is reviewing laboratory results for a client who has a fungal infection and is receiving itraconazole therapy. Which of the following findings should alert the nurse to a potential adverse effect of this medication?

Correct Answer is A

Explanation

Which antibiotics are classified as concentration-dependent antimicrobials?

Which of the following antiviral medications inhibits neuraminidase enzyme?

A nurse is educating a group of travelers who are going to a region where malaria is endemic. Which of the following antimalarial drugs should the nurse recommend for prophylaxis? (Select all that apply.).

A nurse is teaching a client who has been prescribed tetracycline, a tetracycline antibiotic, for acne vulgaris. Which of these instructions should the nurse include in the teaching? (Select all that apply.)

A nurse is preparing to administer flucytosine to a client who has a systemic fungal infection. Which of the following assessments should the nurse perform before giving this medication? (Select all that apply.).

Which term is used to describe an agent that inhibits bacterial growth but does not kill bacteria?

A nurse is caring for a client who has oral candidiasis and is prescribed nystatin suspension. Which of the following actions should the nurse take?

A patient is receiving cefazolin, a first-generation cephalosporin, for a surgical prophylaxis. The nurse should assess the patient for which of the following possible allergic reactions? (Select all that apply.)