Which antibiotics are classified as concentration-dependent antimicrobials?

Ciprofloxacin

Imipenem

Penicillin V

Metronidazole

Gentamicin.

Answer and Explanation

The Correct Answer is E

Gentamicin is an example of a concentration-dependent antimicrobial, which means that it achieves increasing bacterial kill with increasing levels of drug. The peak concentration and the area under the concentration curve (AUC) determine the efficacy of these antibiotics. Other examples of concentration-dependent antimicrobials include fluoroquinolones, daptomycin, aminoglycosides, and amphotericin

Choice A is wrong because ciprofloxacin is a fluoroquinolone, which is also a concentration-dependent antimicrobial.

Choice B is wrong because imipenem is a carbapenem, which is a type of beta-lactam antibiotic. Beta-lactams are time-dependent antimicrobials, which means that their bactericidal activity depends on the duration of the effective concentration.

Choice C is wrong because penicillin V is another type of beta-lactam antibiotic, which is also a time-dependent antimicrobial.

Choice D is wrong because metronidazole is a bactericidal agent that has both time- and concentration-dependent properties. However, it is not classified as a concentration-dependent antimicrobial according to the AMEG categorization of antibiotics in the European Union.

Nursing Test Bank

Quiz #1: RN Exams Pharmacology Exams Quiz #2: RN Exams Medical-Surgical Exams Quiz #3: RN Exams Fundamentals Exams Quiz #4: RN Exams Maternal-Newborn Exams Quiz #5: RN Exams Anatomy and Physiology Exams Quiz #6: RN Exams Obstetrics and Pediatrics Exams Quiz #7: RN Exams Fluid and Electrolytes Exams Quiz #8: RN Exams Community Health Exams Quiz #9: RN Exams Promoting Health across the lifespan Exams Quiz #10: RN Exams Multidimensional care Exams

Get 100+ Naxlex Exit Exams for $79 Try Naxlex NCLEX-RN (14 Day Free-Trial)

Naxlex Comprehensive Predictor Exams

Quiz #1: Naxlex RN Comprehensive online practice 2019 B with NGN Quiz #2: Naxlex RN Comprehensive Predictor 2023 Quiz #3: Naxlex RN Comprehensive Predictor 2023 Exit Exam A Quiz #4: Naxlex HESI Exit LPN Exam Quiz #5: Naxlex PN Comprehensive Predictor PN 2020 Quiz #6: Naxlex VATI PN Comprehensive Predictor 2020 Quiz #8: Naxlex PN Comprehensive Predictor 2023 - Exam 1 Quiz #10: Naxlex HESI PN Exit exam Quiz #11: Naxlex HESI PN EXIT Exam 2

Free Nursing Study Resources

Correct Answer is ["B","C","D"]

Explanation

Choice A is wrong because azithromycin (Zithromax) should be takenwith foodto prevent stomach upset.

Choice B is correct because azithromycin can causeliver damageand the client should report any signs ofjaundiceordark urineas they may indicate liver problems.

Choice C is correct because azithromycin can interact withgrapefruit juiceand increase the risk ofside effectssuch as nausea, vomiting, diarrhea, headache and QT interval prolongation.

Choice D is correct because the client shouldcomplete the full course of therapyas prescribed to prevent bacterial resistance and recurrence of infection.

Choice E is wrong because azithromycin should be stored in arefrigeratorand discarded after 10 days if it is in a liquid form.

A. Urticaria B. Bronchospasm C. Anaphylaxis D. Stevens-Johnson syndrome E. Angioedema.

Correct Answer is ["A","B","C","E"]

Explanation

Cefazolin can cause serious or life-threatening allergic reactions in some patients, especially those with a history of penicillin allergy.The most common allergic reactions to cefazolin are immediate reactions, such as anaphylaxis, urticaria, bronchospasm, and angioedema.These reactions usually occur within one hour of the drug administration and may involve symptoms such as rash, itching, swelling, difficulty breathing, low blood pressure, and shock.Immediate reactions are mediated by immunoglobulin E (IgE) antibodies that bind to the drug and trigger the release of inflammatory mediators from mast cells and basophils.

Choice D is wrong because Stevens-Johnson syndrome is not a typical allergic reaction to cefazolin.

Stevens-Johnson syndrome is a rare and severe skin reaction that can be caused by various drugs, infections, or autoimmune diseases.

It involves blistering and peeling of the skin and mucous membranes, fever, malaise, and eye inflammation.

Stevens-Johnson syndrome is not mediated by IgE antibodies, but by other immune mechanisms that damage the skin cells.

Cefazolin is not known to cause Stevens-Johnson syndrome, although other cephalosporins have been reported to do so in rare cases.

View Question and Answer

Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.

Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today

Which antibiotics are classified as concentration-dependent antimicrobials?

Nursing Test Bank

Naxlex Comprehensive Predictor Exams

A nurse is educating a client who has a respiratory infection and a new prescription for azithromycin (Zithromax). Which of the following instructions should the nurse include? (Select all that apply).

Correct Answer is ["B","C","D"]

Explanation

A patient is receiving cefazolin, a first-generation cephalosporin, for a surgical prophylaxis. The nurse should assess the patient for which of the following possible allergic reactions? (Select all that apply.)

Correct Answer is ["A","B","C","E"]

Explanation

A nurse is teaching a client who has been prescribed tetracycline, a tetracycline antibiotic, for acne vulgaris. Which of these instructions should the nurse include in the teaching? (Select all that apply.)

A nurse is teaching a client who has tuberculosis about the prescribed drug regimen, which includes isoniazid, rifampin, pyrazinamide, and ethambutol. The nurse should instruct the client to report which signs or symptoms as possible adverse effects of these drugs? (Select all that apply.)

A nurse is preparing to administer flucytosine to a client who has a systemic fungal infection. Which of the following assessments should the nurse perform before giving this medication? (Select all that apply.).

A nurse is preparing to administer vancomycin, a glycopeptide antibiotic, to a client with a severe infection caused by Clostridium difficile. The nurse should select all that apply:

A nurse is caring for a client who has oral candidiasis and is prescribed nystatin suspension. Which of the following actions should the nurse take?

A nurse is caring for a client who has tuberculosis and is prescribed rifampin, an antitubercular drug. The nurse should instruct the client about which potential side effect of rifampin?

A nurse is preparing to administer ceftriaxone (Rocephin) to a client who has pneumonia caused by Streptococcus pneumoniae. The nurse should recognize that ceftriaxone belongs to which generation of cephalosporins?