Which acid-base mechanism would the kidney use to buffer a patient's acidosis (serum pH <7.35)? Select all that apply.
One, some, or all responses may be correct.

Choice A rationale:

Anemia is not a direct manifestation of target organ damage from hypertension.

Choice B rationale:

Aneurysm is a correct answer. Persistent high blood pressure can weaken the walls of arteries, making them more susceptible to forming an aneurysm. Aneurysms can occur in various arteries, such as the aorta, and can lead to life-threatening complications if they rupture.

Choice C rationale:

Proteinuria is also a correct answer. Hypertension can damage the kidneys, leading to proteinuria, the presence of excess proteins in the urine. This is an indication of kidney damage and is a common manifestation of hypertensive target organ disease.

Choice D rationale:

Pneumonia and Transient Ischemic Attack (TIA) are not direct manifestations of target organ damage from hypertension.

Choice A rationale:

Serotonin is a neurotransmitter that plays a role in mood regulation, sleep, and other functions in the body. It is not a component that forms an adhesive bridge between platelets and vascular subendothelial structures in the clotting process.

Choice B rationale:

Platelet factor III is not a component that forms an adhesive bridge between platelets and vascular subendothelial structures in the clotting process. Platelet factor III is not widely recognized in the context of clotting; it is more commonly referred to as tissue factor and is involved in the extrinsic pathway of coagulation.

Choice C rationale:

Von Willebrand factor (VWF) is a protein that plays a crucial role in hemostasis. It forms an adhesive bridge between platelets and vascular subendothelial structures, particularly at sites of vascular injury. VWF helps platelets adhere to the injured vessel wall, leading to the formation of a stable blood clot. This process is essential for preventing excessive bleeding. A deficiency or dysfunction in VWF can lead to von Willebrand disease, a bleeding disorder characterized by prolonged bleeding times.

Choice D rationale:

Adenosine diphosphate (ADP) is a molecule released by platelets when they are activated. ADP helps in the aggregation of platelets, but it does not directly form an adhesive bridge between platelets and vascular subendothelial structures.