What signs and symptoms are associated with a hypersensitivity reaction that can present with a Cephalosporin?

Skin rash

Hyperglycemia

Dizziness

Intense pruritus

Answer and Explanation

Correct Answer : A,D

Signs and symptoms associated with a hypersensitivity reaction to cephalosporin antibiotics can include:

1. Skin rash: Hypersensitivity reactions often manifest as skin rashes, which can range from mild to severe. The rash may be itchy, red, raised, and may spread to different areas of the body.

2. Intense pruritus: Pruritus refers to severe itching, which can be a prominent symptom of a hypersensitivity reaction to cephalosporins.

Dizziness and hyperglycemia are not commonly associated with hypersensitivity reactions to cephalosporins. Dizziness may be a side effect of some medications, including antibiotics, but it is not a specific symptom of a hypersensitivity reaction. Hyperglycemia, or high blood sugar levels, is not typically attributed to a hypersensitivity reaction to cephalosporins. It's important to note that hypersensitivity reactions can vary in severity and may include other symptoms such as fever, swelling, difficulty breathing, wheezing, and anaphylaxis. If a hypersensitivity reaction is suspected, it is crucial to seek immediate medical attention for proper evaluation and management.

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Correct Answer is D

Explanation

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of medications commonly used to relieve pain, reduce inflammation, and lower fever. They work by inhibiting the production of prostaglandins, which are substances in the body that play a role in pain and inflammation. Celecoxib specifically belongs to the subclass of NSAIDs known as selective COX-2 inhibitors, which target the enzyme cyclooxygenase-2 (COX-2). By selectively inhibiting COX-2, celecoxib helps to reduce inflammation and pain while potentially minimizing the gastrointestinal side effects associated with traditional non-selective NSAIDs.

A. Melena B. Decreased vision C. Pancytopenia D. Hyperglycemia

Correct Answer is C

Explanation

Pancytopenia refers to a decrease in all three major blood cell types: red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). It is a potentially serious side effect that can lead to increased susceptibility to infections, anemia-related symptoms (fatigue, weakness), and an increased risk of bleeding. Prompt reporting is necessary for further

evaluation and appropriate management.

While melena (dark, tarry stools) is a concerning side effect, it typically indicates gastrointestinal bleeding, which should also be reported promptly but may not require immediate action unless the bleeding is severe or accompanied by other symptoms.

Decreased vision can be a side effect of certain medications, including NSAIDs, but it does not usually require immediate reporting unless it is severe or rapidly progressive. Hyperglycemia (high blood sugar) can occur with NSAID therapy, especially in individuals with preexisting diabetes or impaired glucose tolerance. While it should be monitored and managed appropriately, it does not typically require immediate reporting unless it is extremely high or associated with other concerning symptoms.

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What signs and symptoms are associated with a hypersensitivity reaction that can present with a Cephalosporin?

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