What is the term used for a well understood drug model with which other drugs in its representative class are compared?

Choice A reason: Ancef (ciprofloxacin) is not the correct answer for the nurse who anticipates administering a broad-spectrum antibiotic to a client diagnosed with a beta lactam resistant bacteria. Ancef is the brand name of cefazolin, which is a firstgeneration cephalosporin, a subclass of beta lactam antibiotics. Cefazolin is effective against gram-positive bacteria, but has limited activity against gram negative bacteria and anaerobes. Cefazolin is also susceptible to beta-lactamase enzymes, which are produced by some bacteria to degrade beta lactam antibiotics and confer resistance. The nurse should avoid using Ancef or any other beta lactam antibiotic for a client with a beta lactam resistant bacteria.

Choice B reason: Merrem (meropenem) is the correct answer for the nurse who anticipates administering a broad-spectrum antibiotic to a client diagnosed with a beta lactam resistant bacteria. Merrem is the brand name of meropenem, which is a carbapenem, a subclass of beta lactam antibiotics. Meropenem is effective against a wide range of bacteria, including gram-positive, gram negative, and anaerobic bacteria. Meropenem is also resistant to most beta-lactamase enzymes, except for metallo-beta-lactamase’s, which are rare and can be detected by laboratory tests. The nurse should consider using Merrem or another carbapenem for a client with a beta lactam resistant bacteria, unless they have a history of allergy or intolerance to beta lactam antibiotics .

Choice C reason: Flagyl (metronidazole) is not the correct answer for the nurse who anticipates administering a broad spectrum antibiotic to a client diagnosed with a beta lactam resistant bacteria. Flagyl is the brand name of metronidazole, which is a nitroimidazole antibiotic. Metronidazole is effective against anaerobic bacteria and some protozoa, but has no activity against aerobic bacteria. Metronidazole is not a beta lactam antibiotic, and it is not affected by beta-lactamase enzymes. However, metronidazole is not a broad spectrum antibiotic, and it is not suitable for treating infections caused by aerobic bacteria, which are more common than anaerobic bacteria. The nurse should use Flagyl only for specific indications, such as bacterial vaginosis, trichomoniasis, or Clostridioides difficile infection .

Choice D reason: Zosyn (piperacillin tazobactam) is not the correct answer for the nurse who anticipates administering a broad-spectrum antibiotic to a client diagnosed with a beta lactam resistant bacterium. Zosyn is the brand name of piperacillin tazobactam, which is a combination of penicillin, a subclass of beta lactam antibiotics, and a beta-lactamase inhibitor. Piperacillin is effective against some gram-positive and gram-negative bacteria, but it is susceptible to beta-lactamase enzymes. Tazobactam is a compound that binds to and inhibits some beta-lactamase enzymes, thereby protecting piperacillin from degradation and extending its spectrum of activity. However, piperacillin tazobactam is not effective against all types of beta-lactamase enzymes, especially those that are encoded by plasmids and can be transferred between bacteria. The nurse should not use Zosyn or any other beta lactam/beta-lactamase inhibitor combination for a client with a beta lactam resistant bacterium unless the specific type of beta-lactamase is known and susceptible to the inhibitor.

Choice A reason: This is incorrect. Fluticasone is a corticosteroid that is used to treat asthma and allergic rhinitis. It does not affect the patient's ability to exercise or engage in strenuous activity. In fact, exercise can help improve lung function and reduce inflammation.

Choice B reason: This is incorrect. Fluticasone does not affect the patient's potassium levels. Potassium is an electrolyte that is important for the function of the heart, muscles, and nerves. Some medications, such as diuretics, can lower potassium levels and require the patient to eat potassium rich foods, such as bananas, potatoes, and tomatoes. Fluticasone is not one of them.

Choice C reason: This is correct. Fluticasone can cause hyperglycemia, which is high blood sugar. This can occur because corticosteroids can increase the production of glucose in the liver and reduce the sensitivity of the cells to insulin, the hormone that regulates blood sugar. Hyperglycemia can cause symptoms such as increased thirst, hunger, urination, fatigue, and blurred vision. The patient should monitor their blood sugar levels regularly and report any changes to their doctor.

Choice D reason: This is incorrect. Fluticasone does not affect the patient's digestion or appetite. It can be taken with or without food. There is no need to avoid eating for 4 hours after taking Fluticasone. However, the patient should rinse their mouth with water after using Fluticasone inhaler or nasal spray, as this can help prevent oral thrush, a fungal infection that can cause white patches, soreness, and bleeding in the mouth.