The overall number of cases of STIs is:

Choice A reason: Hyperbilirubinemia is incorrect because it is not a major complication of infants of diabetic mothers. It is a condition where the baby has high levels of bilirubin in the blood, which can cause jaundice. It can occur in any newborn, but it is more common in premature babies, babies with blood type incompatibility, or babies with infections.

Choice B reason: Hypoglycemia is correct because it is a major complication of infants of diabetic mothers. It is a condition where the baby has low blood sugar levels, which can cause seizures, lethargy, or poor feeding. It can occur because the baby's pancreas produces too much insulin in response to the mother's high blood sugar levels during pregnancy.

Choice C reason: Hypoinsulinemia is incorrect because it is not a major complication of infants of diabetic mothers. It is a condition where the body does not produce enough insulin, which can cause high blood sugar levels. It can occur in children or adults with type 1 diabetes, but not in newborns of diabetic mothers.

Choice D reason: Hypercalcemia is incorrect because it is not a major complication of infants of diabetic mothers. It is a condition where the baby has high levels of calcium in the blood, which can cause muscle weakness, vomiting, or kidney stones. It can occur in babies with certain genetic disorders, such as Williams syndrome, or babies with hyperparathyroidism, but not in infants of diabetic mothers.

Choice A reason: Syphilis is not caused by a virus, but by a bacterium called Treponema pallidum. It can also be spread through unprotected sex, but it has different stages and symptoms than herpes. Syphilis can be cured with antibiotics if detected early.

Choice B reason: HIV/AIDS is caused by a virus, but not one that is related to the virus that causes chickenpox. HIV stands for human immunodeficiency virus, which attacks the immune system and can lead to AIDS (acquired immunodeficiency syndrome). HIV can be spread through unprotected sex, but also through other means such as blood transfusion or sharing needles. HIV cannot be cured, but antiretroviral therapy can help control the infection and prevent AIDS.

Choice C reason: Gonorrhea is not caused by a virus, but by a bacterium called Neisseria gonorrhoeae. It can be spread through unprotected sex, but it usually causes symptoms such as discharge, burning, or pain in the genitals, anus, or throat. Gonorrhea can be cured with antibiotics, but some strains are resistant to treatment.

Choice D reason: Herpes simplex virus is caused by a virus that is related to the virus that causes chickenpox. There are two types of herpes simplex virus: HSV-1 and HSV-2. HSV-1 usually causes oral herpes (cold sores), while HSV-2 usually causes genital herpes. However, both types can infect either area. Herpes can be spread through any form of unprotected sex, and can be transmitted even when there are no visible sores. Herpes has no cure, but antiviral medications can help reduce the frequency and severity of outbreaks.