In which stage of the HIV lifecycle does the enzyme integrase play a crucial role, and what is its function in that stage?
Assembly. Integrase packages the viral RNA into new virions.
Integration: Integrase inserts viral DNA into the host's genome.
Entry: Integrase helps the virus fuse with the host cell membrane.
Reverse Transcription: Integrase copies viral RNA into DNA.
The Correct Answer is B
A. In the assembly stage, other proteins and enzymes are involved in the packaging of viral components into new virions, not integrase.
B. During the integration stage, integrase is essential as it inserts the newly formed viral DNA into the host's genome, enabling the virus to utilize the host's cellular machinery for replication.
C. Integrase does not participate in the entry stage; this stage is facilitated by other proteins that aid in the fusion of the virus with the host cell membrane.
D. Integrase is not involved in reverse transcription; that process is facilitated by the enzyme reverse transcriptase, which converts viral RNA into DNA.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
A. Gingivitis is a form of gum disease that can occur in anyone, but it is not specifically related to low CD4-T-cell counts associated with AIDS.
B. Candidiasis, also known as oral thrush, is a fungal infection caused by Candida species. Clients with a significantly decreased CD4-T-cell count are at high risk for opportunistic infections, including candidiasis, due to their compromised immune systems.
C. Xerostomia refers to dry mouth, which can occur for various reasons but is not specifically an infectious condition linked to low CD4 counts.
D. Halitosis, or bad breath, can result from several factors, including poor oral hygiene or underlying health issues, but is not specifically linked to the immune status of a client with AIDS.
Correct Answer is A
Explanation
A. The CD4-T-cell count of 180 cells/mm3 is a critical measure of immune function in an HIV-positive client, indicating progression of the disease and risk for opportunistic infections. Values below 200 cells/mm3 signify the client has progressed to AIDS.
B. A positive Western blot test confirms the presence of HIV but does not indicate the immediate health risk or necessary interventions.
C. A platelet count of 150,000/mm3 is within the normal range, thus not indicative of any urgent concerns.
D. A WBC count of 5,000/mm3 is also within normal limits and does not highlight an immediate issue that needs addressing compared to the CD4 count.
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