In which stage of the HIV lifecycle does the enzyme integrase play a crucial role, and what is its function in that stage?

Assembly. Integrase packages the viral RNA into new virions.

Integration: Integrase inserts viral DNA into the host's genome.

Entry: Integrase helps the virus fuse with the host cell membrane.

Reverse Transcription: Integrase copies viral RNA into DNA.

Answer and Explanation

The Correct Answer is B

A. In the assembly stage, other proteins and enzymes are involved in the packaging of viral components into new virions, not integrase.
B. During the integration stage, integrase is essential as it inserts the newly formed viral DNA into the host's genome, enabling the virus to utilize the host's cellular machinery for replication.
C. Integrase does not participate in the entry stage; this stage is facilitated by other proteins that aid in the fusion of the virus with the host cell membrane.
D. Integrase is not involved in reverse transcription; that process is facilitated by the enzyme reverse transcriptase, which converts viral RNA into DNA.

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Correct Answer is ["D","E","F","G"]

Explanation

D. Measure lactate level: Elevated lactate levels are a strong indicator of sepsis and can help guide treatment.

E. Administer broad-spectrum antibiotics: Prompt administration of antibiotics is crucial to combat the infection.

F. Rapidly administer 30 mL/kg of normal saline: Aggressive fluid resuscitation is necessary to improve blood pressure and tissue perfusion.

G. Obtain blood cultures: Blood cultures can help identify the specific organism causing the infection and guide antibiotic therapy.

Other interventions that may be considered, but not necessarily within the first hour, include:

A. Obtain a urine specimen: This can help identify a urinary tract infection as a potential source of sepsis.

B. Insert a nasogastric tube: This may be necessary if the client is unable to tolerate oral intake or requires gastric decompression.

C. Type and cross-match for 2 units of packed RBCs: This may be necessary if the client develops significant anemia or requires blood transfusion.

A. IV antibiotics B. Urinalysis C. Chest x-ray D. Chest tube placement E. Admit to inpatient F. Airborne precautions G. Draw an STI lab panel H. Complete blood count

Correct Answer is ["A","C","E","H"]

Explanation

The nurse anticipates the following orders from the provider based on the suspected diagnosis:

A. IV antibiotics: To treat the suspected infection.
C. Chest x-ray: To assess the lungs for signs of infection, such as pneumonia.
E. Admit to inpatient: The client's worsening condition and need for aggressive treatment warrant hospitalization.
H. Complete blood count: To assess the client's overall health status and identify any abnormalities, such as anemia or infection.

Rationale:

B. Urinalysis: While a urinalysis can be helpful in assessing for urinary tract infections, it is not a priority in this case.
D. Chest tube placement: This is not indicated unless the client develops a pleural effusion or pneumothorax.
F. Airborne precautions: This is not necessary for the client's current condition.
G. Draw an STI lab panel: While this may be relevant for the client's overall health, it is not a priority at this time, especially given the client's acute presentation.

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In which stage of the HIV lifecycle does the enzyme integrase play a crucial role, and what is its function in that stage?

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Naxlex Comprehensive Predictor Exams

A nurse is caring for a 73-year-old client in the emergency department (ED) Exhibits It has been identified that the client is in sepsis. Select the 4 actions that the nurse should complete in the first hour to manage sepsis and prevent further complications?

Correct Answer is ["D","E","F","G"]

Explanation

A nurse is caring for a client in the clinic. Exhibits The nurse anticipates which of the following orders from the provider based on the suspected diagnosis? (Select all that apply)

Correct Answer is ["A","C","E","H"]

Explanation

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