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An older client may be at higher risk for medication toxicity due to which of the following physiological changes associated with aging?

A.

Reduced hepatic blood flow

B.

Reduced body fat

C.

Increased glomerular filtration rate

D.

Increased gastric motility

Answer and Explanation

The Correct Answer is A

Reduced hepatic blood flow can decrease the metabolism and excretion of many drugs, requiring that doses of some drugs be decreased ². This can increase the risk of medication toxicity in older adults.
Option B is not correct because reduced body fat is not a physiological change associated with aging. 
Option C is not correct because the glomerular filtration rate decreases with age ². 
Option D is not correct because gastric motility decreases with age ².


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Related Questions

Correct Answer is D

Explanation

According to web search results, the total phenytoin reference range for children and adults is **10-20 µg/mL**¹. This means that a level of 17 mcg/mL falls within the therapeutic range.
Option A is within the therapeutic range but is on the lower end.
Option B is below the therapeutic range.
Option C is above the therapeutic range and could be considered toxic.

Correct Answer is C

Explanation

A half-life is the time it takes for the concentration of a drug in the body to decrease by half. In this case, the medication has an 8-hour half-life, so after 8 hours, the concentration of the medication in the client's body would be reduced to 400mg (half of the initial dose of 800mg). After another 8 hours (16 hours total), the concentration would be reduced to 200mg. After another 8 hours (24 hours total), the concentration would be reduced to 100mg.

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