All of the following are first generation antipsychotics except,

A. Repeated passage of saliva into clothing. There is no recognized disorder characterized by excessive saliva passage onto clothing. However, sialorrhea (excessive drooling) may occur in neurological conditions like cerebral palsy or as a side effect of medications like clozapine.

B. Repeated passage of feces into clothing. Encopresis is the repeated, involuntary or intentional passage of feces into inappropriate places, such as clothing or the floor, in children older than 4 years. It is often associated with chronic constipation, stool retention, and overflow incontinence, though it can also occur in response to emotional stress or behavioral issues.

C. Repeated passage of rights. This phrase does not correspond to any recognized medical or psychiatric condition.

D. Repeated voiding of urine into bed or clothing. This describes enuresis, not encopresis. Enuresis is the repeated involuntary or intentional voiding of urine into bed or clothing, occurring at least twice a week for three consecutive months in children older than 5 years. It can be nocturnal (night-time bedwetting), diurnal (daytime), or both.

A. Clozapine (Clozaril) is a second-generation (atypical) antipsychotic known for its strong dopamine (D2) and serotonin (5-HT2A) blockade. It is primarily used for treatment-resistant schizophrenia but has a high risk of agranulocytosis, metabolic syndrome, and sedation, requiring regular blood monitoring.

B. Haloperidol (Haldol) is a first-generation (typical) antipsychotic that strongly blocks dopamine (D2) receptors, leading to a high risk of extrapyramidal symptoms (EPS) such as dystonia, tardive dyskinesia, and akathisia. It is commonly used for acute psychosis and agitation.

C. Fluphenazine (Prolixin is a first-generation antipsychotic that also strongly antagonizes D2 receptors, making it effective for chronic schizophrenia but highly associated with EPS. It is available in long-acting injectable (LAI) form for maintenance therapy.

D. Chlorpromazine (Thorazine) is a first-generation, low-potency antipsychotic with strong sedative, anticholinergic, and hypotensive effects. While it has a lower risk of EPS compared to high-potency FGAs like haloperidol, it causes more sedation, orthostatic hypotension, and weight gain due to histamine and muscarinic receptor blockade.