A patient with diabetic peripheral neuropathy has been taking pregabalin for the past four days. Which finding would indicate to the nurse that the medication is effective?

Choice A rationale
A chest x-ray is a critical diagnostic tool for a patient presenting with flu-like symptoms, fever, chest congestion, and increased breathing difficulties. It can help identify conditions such as pneumonia or other lung diseases, which could be causing the patient’s symptoms.
Choice B rationale
While hydration is important, running a 0.9% sodium chloride IV infusion at 150 mL/hour is not the most immediate need for this patient. The patient’s symptoms are primarily respiratory, and there is no indication of dehydration.
Choice C rationale
A sputum culture could be useful for diagnosing bacterial infections of the respiratory tract. However, it is not the most immediate need for this patient, as the results of a culture test can take time to come back.
Choice D rationale
This is the correct answer. Given the patient’s increased breathing difficulties, starting oxygen therapy can help improve the patient’s oxygen levels and ease their breathing.
Choice E rationale

Starting a peripheral IV might be necessary for administering medications or fluids, but it is not the most immediate need in this scenario.
Choice F rationale
While controlling the patient’s fever is important, it is not as immediate a need as performing a chest x-ray and starting oxygen therapy.

The correct answer is Choice A

Choice A rationale: Crohn’s disease involves transmural inflammation of the gastrointestinal tract, often leading to hypermotility and increased peristalsis. Activity restriction reduces sympathetic stimulation, thereby minimizing intestinal motility and mechanical stress on inflamed mucosa. This helps prevent exacerbation of symptoms and promotes mucosal rest. By limiting physical exertion, the body can redirect energy toward immune modulation and tissue repair. Normal bowel motility varies, but excessive activity worsens inflammation and nutrient malabsorption in Crohn’s pathology.

Choice B rationale: While diarrhea is a common symptom in Crohn’s disease, activity restriction does not directly modulate stool frequency or water reabsorption. Diarrhea results from mucosal damage, cytokine-mediated secretion, and impaired absorption, not physical activity. Management typically involves anti-inflammatory agents, antidiarrheals, and dietary modifications. Restricting movement may indirectly reduce diarrhea by decreasing intestinal stimulation, but it is not the primary mechanism. Stool water content normally ranges from 60–85%, and inflammation disrupts this balance.

Choice C rationale: Healing in Crohn’s disease is multifactorial, involving immunosuppression, mucosal regeneration, and nutritional support. While rest contributes to systemic recovery, it is not the primary driver of mucosal healing. Healing requires suppression of TNF-alpha, IL-6, and other pro-inflammatory mediators. Activity restriction may support healing indirectly by reducing metabolic demand and stress hormone release, but pharmacologic and nutritional interventions are more central. Normal mucosal turnover occurs every 3–5 days, but inflammation delays this process.

Choice D rationale: Abdominal pain in Crohn’s disease arises from transmural inflammation, bowel distension, and neural sensitization. Although rest may reduce visceral stimulation, pain control is better achieved through anti-inflammatory therapy, bowel rest, and analgesics. Activity restriction does not directly modulate nociceptive pathways or cytokine levels. Pain perception involves complex neuroimmune interactions, and physical rest alone cannot address the underlying pathology. Normal visceral pain thresholds are altered in Crohn’s due to chronic inflammation and fibrosis.