A patient diagnosed with rheumatoid arthritis is about to begin therapy with Etanercept, a tumor necrosis factor antagonist. The nurse anticipates the patient will be tested for
CYP450 genetic variants.
HLA-B genetic variants.
latent hepatitis B virus.
Blood type and crossmatch.
The Correct Answer is C
Choice A rationale: Testing for CYP450 genetic variants is more relevant for medications metabolized by the cytochrome P450 system.
Choice B rationale: HLA-B genetic variants are more associated with certain drug hypersensitivity reactions, not specifically for etanercept.
Choice C rationale: Etanercept can increase the risk of reactivating latent infections, including hepatitis B. Screening for latent hepatitis B virus is essential before starting therapy.
Choice D rationale: Blood type and crossmatch are not typically required for starting etanercept therapy.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A rationale: While methotrexate can help prevent fatal toxicities associated with rheumatoid arthritis, this is not the primary reason for its use in this context.
Choice B rationale: This is correct. Starting methotrexate early in the course of rheumatoid arthritis can help delay the disease process of joint degeneration and prevent irreversible damage.
Choice C rationale: While controlling symptoms is important for the patient's quality of life, starting methotrexate is more about preventing joint damage and progression of the disease than increasing life expectancy.
Correct Answer is D
Explanation
Choice A rationale: Protamine sulfate is used to reverse the anticoagulant effects of heparin, not the effects of alprazolam.
Choice B rationale: Acetylcysteine is the antidote for acetaminophen (paracetamol) overdose and is not effective for alprazolam overdose.
Choice C rationale: Naloxone is an opioid antagonist and is not effective for benzodiazepine overdose.
Choice D rationale: This is correct. Flumazenil is a specific antagonist for benzodiazepines and can be used to reverse the sedative effects of alprazolam in the case of overdose.
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