A nurse is preparing to administer vancomycin 50 mg PO daily divided into four equal doses. The amount available is vancomycin 125 mg capsules. How many capsules should the nurse administer with each dose?

(Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

Choice A reason: Hypothermia

Hypothermia, or abnormally low body temperature, is not a typical manifestation of acute osteomyelitis. Osteomyelitis usually presents with signs of infection, such as fever, rather than a drop in body temperature. Therefore, hypothermia is not a relevant symptom in this context.

Choice B reason: Localized edema

Localized edema, or swelling, is a common symptom of acute osteomyelitis. The infection in the bone can cause inflammation and swelling in the surrounding tissues. This is often accompanied by warmth and redness over the affected area. Therefore, localized edema is a key manifestation of acute osteomyelitis.

Choice C reason: Numbness of toes on the affected foot

Numbness of the toes is not a typical symptom of acute osteomyelitis. While nerve involvement can occur in severe cases, it is not a primary manifestation. Acute osteomyelitis primarily presents with signs of infection and inflammation, such as pain, swelling, and redness.

Choice D reason: Bradycardia

Bradycardia, or a slow heart rate, is not associated with acute osteomyelitis. The condition typically presents with systemic signs of infection, such as fever and malaise, rather than changes in heart rate. Bradycardia is more commonly related to cardiac conditions or certain medications.

Choice A reason: Administer a test dose first

Administering a test dose is not typically required for theophylline. Theophylline dosing is usually based on the patient’s weight and serum theophylline levels. A test dose is more commonly associated with medications that have a high risk of allergic reactions or require desensitization protocols, which is not the case with theophylline.

Choice B reason: Infuse the medication with an IV pump

Using an IV pump to infuse theophylline is essential to ensure accurate and controlled delivery of the medication. Theophylline has a narrow therapeutic range, and precise dosing is crucial to avoid toxicity. An IV pump allows for consistent infusion rates, reducing the risk of adverse effects. This is the most appropriate action for the nurse to take.

Choice C reason: Cover the IV container with dark paper

There is no need to cover the IV container with dark paper when administering theophylline. Theophylline is not light-sensitive, so this precaution is unnecessary. Covering IV containers is typically done for medications that degrade when exposed to light, such as certain antibiotics and chemotherapy agents.

Choice D reason: Infuse the medication at 35 mg/min

Infusing theophylline at a rate of 35 mg/min is excessively high and could lead to severe toxicity. The infusion rate for theophylline should be carefully calculated based on the patient’s weight and serum levels, and it is typically much lower than 35 mg/min. Rapid infusion can cause serious side effects, including arrhythmias and seizures.