A nurse is preparing to administer midazolam 0.2 mg/kg via IV bolus now. The client weighs 220 lb. How many mg should the nurse administer?

(Round the answer to the nearest whole number. Use a leading zero if it applies. Do not use a trailing zero.)

A. The client's blood pressure is within the expected reference range - While blood pressure monitoring is important during treatment with certain medications, such as antihypertensives, it is not a direct indicator of the effectiveness of sertraline, which is an antidepressant medication.

B. The client's legs are not swollen - Swelling of the legs may be a sign of fluid retention, which can occur with various conditions and medications. However, it is not a specific indicator of the effectiveness of sertraline.

C. The client reports a recent weight loss - Weight changes, including weight loss or gain, can occur as side effects of sertraline. However, weight changes alone do not necessarily indicate the effectiveness of the medication in treating depression.

D. The client reports an increase in mood - Improvement in mood, reduction in depressive symptoms, and overall sense of well-being are primary indicators of the effectiveness of sertraline and other antidepressant medications in treating depression. Therefore, the client reporting an increase in mood suggests that the medication may be effective in managing their symptoms.

Alprazolam is a benzodiazepine medication commonly used to treat anxiety and insomnia. Here's the rationale for each option:

A. "Avoid activities that require alertness, such as driving.": Alprazolam can cause drowsiness and impair cognitive function, so it's essential for clients to avoid activities that require alertness, such as driving or operating heavy machinery, while taking this medication. Providing this instruction promotes safety and prevents accidents.

B. "Monitor for peripheral edema.": Peripheral edema is not a common side effect of alprazolam. This instruction is not relevant to the use of this medication.

C. "Take this medication with a high-fat meal.": Alprazolam can be taken with or without food, but taking it with a high-fat meal may delay its absorption. Therefore, it is not necessary to instruct the client to take it with a high-fat meal, especially since this may affect the medication's effectiveness.

D. "Take this medication every night before sleep.": While alprazolam may be used to treat insomnia, it is not typically recommended for nightly use due to the risk of dependence and tolerance. Using it nightly can lead to addiction and withdrawal symptoms if abruptly stopped. Therefore, this instruction is not appropriate.