A nurse is caring for a client who has chronic renal failure and is receiving epoetin alfa. To check for therapeutic effects, the nurse should monitor which of the following client laboratory tests?

Hemoglobin levels

Iron levels

Platelet count

White blood cell count

Answer and Explanation

The Correct Answer is A

A. Hemoglobin levels. Epoetin alfa stimulates erythropoiesis (red blood cell production) in clients with chronic renal failure, where natural erythropoietin production is impaired. The therapeutic effect of epoetin alfa is measured by monitoring hemoglobin (Hgb) levels to ensure adequate response without exceeding safe limits. Target Hgb levels should not exceed 11 g/dL, as higher levels increase the risk of thromboembolic events and hypertension.

B. Iron levels. While iron is necessary for red blood cell production, epoetin alfa does not directly affect iron levels. However, iron supplementation may be required if iron deficiency is present, as inadequate iron stores can limit the effectiveness of epoetin alfa therapy.

C. Platelet count. Epoetin alfa primarily affects red blood cell production and has no direct effect on platelet levels. Although polycythemia (excess red blood cells) can increase the risk of clot formation, platelet count is not the primary indicator of epoetin alfa’s therapeutic effects.

D. White blood cell count. Epoetin alfa does not impact white blood cell (WBC) production. Leukocyte production is regulated by different growth factors, and WBC monitoring is more relevant for conditions such as infections, chemotherapy-induced neutropenia, or bone marrow disorders.

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Correct Answer is A

Explanation

A. Rash. A rash while taking allopurinol can indicate a serious hypersensitivity reaction, including Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). These life-threatening conditions involve widespread skin blistering, mucosal involvement, and systemic symptoms. Immediate discontinuation of allopurinol and medical intervention are required to prevent severe complications.

B. Diarrhea. Mild gastrointestinal disturbances, including diarrhea, are common with allopurinol use. While bothersome, diarrhea is not life-threatening and can often be managed by adjusting the dose or taking the medication with food. It does not require immediate discontinuation unless severe or persistent.

C. Nausea. Nausea is a common, mild side effect of allopurinol that usually resolves with time or by taking the medication after meals. It is not an emergency and does not require urgent intervention unless accompanied by other concerning symptoms such as vomiting or severe abdominal pain.

D. Metallic taste in mouth. A metallic taste can occur with allopurinol use but is not harmful. It is a minor side effect that does not indicate toxicity or severe adverse reactions. Clients can be reassured that this effect is temporary and not a reason to stop the medication.

A. Premedicate the client with diphenhydramine. B. Request a different route of administration from the provider. C. Administer the medication to the client. D. Request a different medication from the provider.

Correct Answer is C

Explanation

A. Premedicate the client with diphenhydramine. Premedicating with diphenhydramine is not necessary unless the client has a history of mild allergic reactions to erythromycin. Erythromycin is a macrolide antibiotic and does not have significant cross-reactivity with penicillin, making premedication unnecessary.

B. Request a different route of administration from the provider. Changing the route of administration does not address concerns about allergy. Erythromycin is well tolerated in clients with a penicillin allergy, and there is no indication that a different route would be required unless the client has difficulty swallowing or gastrointestinal intolerance.

C. Administer the medication to the client. Erythromycin belongs to the macrolide class and is commonly prescribed as an alternative for clients allergic to penicillin. There is no cross-reactivity between macrolides and penicillins, making erythromycin a safe and effective option for treating bacterial infections in these clients.

D. Request a different medication from the provider. There is no need to request an alternative medication unless the client has a known allergy to erythromycin. Since macrolides are safe for clients with penicillin allergies, withholding the medication without a valid reason could delay necessary treatment.

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A nurse is caring for a client who has chronic renal failure and is receiving epoetin alfa. To check for therapeutic effects, the nurse should monitor which of the following client laboratory tests?

Nursing Test Bank

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Explanation

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