A nurse is caring for a client who has an acute ankle sprain.Which of the following actions should the nurse take? (Select all that apply.)

Choice A rationale

Aspirin (acetylsalicylic acid) at a low daily dose of 81 mg is typically used for its antiplatelet effects (irreversible inhibition of COX-1 in platelets) to prevent cardiovascular events. This dose has minimal analgesic or anti-inflammatory effects. Therefore, monitoring a pain rating of 6 or more is not a primary concern for this specific prophylactic indication.

Choice B rationale

Encouraging increased intake of green leafy vegetables, which are rich in Vitamin K, is relevant for clients on warfarin (Coumadin), as Vitamin K can counteract its effect. Aspirin, however, works on platelet aggregation and is not affected by dietary Vitamin K levels. This advice is irrelevant to the pharmacodynamics of aspirin.

Choice C rationale

Aspirin is a non-steroidal anti-inflammatory drug (NSAID) that can cause gastrointestinal irritation and bleeding, a side effect that is dose-dependent but still possible with low-dose therapy. Black, tarry stools (melena) are an indication of upper gastrointestinal bleeding due to the degradation of hemoglobin to hematin. The nurse must monitor for this serious adverse effect.

Choice D rationale

Aspirin, especially at higher doses, can impair renal function by inhibiting prostaglandin synthesis, which is essential for maintaining renal blood flow. This effect typically leads to an increase (not a sudden drop) in blood urea nitrogen (BUN) (normal range 8-20 mg/dL) and creatinine (normal range 0.6-1.2 mg/dL) levels due to decreased glomerular filtration.

Choice A rationale

Polyuria is defined as excessive or abnormally large production or passage of urine, often greater than 2.5 liters in a 24-hour period. It is typically associated with conditions like diabetes mellitus (osmotic diuresis) or diabetes insipidus (deficiency of antidiuretic hormone). A routine urinary tract infection (UTI) usually presents with symptoms like increased frequency and urgency, but not necessarily an increase in total urine volume.

Choice B rationale

Urinary frequency is a classic symptom of a urinary tract infection (UTI), particularly cystitis (bladder infection). Inflammation and irritation of the bladder lining (urothelium) caused by the colonizing bacteria (often E. coli) lead to increased sensitivity and involuntary detrusor muscle contractions, resulting in a persistent, urgent, and frequent need to void small amounts of urine.

Choice C rationale

Dysuria, or painful and difficult urination, is a hallmark clinical manifestation of a urinary tract infection (UTI). The discomfort arises from the inflammatory response in the urethra and bladder lining (mucosa) as the body attempts to fight the bacterial invasion, causing a burning sensation, especially upon the passage of acidic urine over the inflamed tissues.

Choice D rationale

Dependent edema is the accumulation of excess interstitial fluid in the body's lower extremities due to the effect of gravity, often associated with systemic conditions like heart failure (elevated venous pressure) or renal disease (proteinuria/hypoalbuminemia). It is not a typical or expected finding directly associated with an uncomplicated, localized urinary tract infection (UTI).

Choice E rationale

Hematuria, the presence of blood in the urine, is a common finding in urinary tract infections (UTIs), especially cystitis. Inflammation and damage to the delicate capillary walls and mucosal lining of the bladder and lower urinary tract by the invading bacteria (e.g., E. coli) and the host's immune response can lead to the leakage of red blood cells into the urine.