A newly diagnosed patient is prescribed lithium. Which information from the patient's history indicates that monitoring of serum concentrations of the drug will be challenging and critical?
Arthritis
Heart failure
Psoriasis
Epilepsy
The Correct Answer is B
Rationale:
A. Arthritis does not typically affect lithium metabolism or clearance.
B. Heart failure can impair renal function and fluid balance, increasing the risk of lithium toxicity and making serum concentration monitoring critical.
C. Psoriasis does not interfere with lithium pharmacokinetics.
D. Epilepsy is not directly related to lithium metabolism, though caution is warranted if the patient is on other medications.
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Related Questions
Correct Answer is B
Explanation
Rationale:
A. Shortness of breath and chronic cough are not typical early signs of lithium toxicity; these suggest possible respiratory or cardiac issues unrelated to lithium.
B. Early signs of lithium toxicity include gastrointestinal upset (nausea, diarrhea) and neuromuscular effects such as weakness.
C. ECG changes and chest pain can occur with severe toxicity, but they are not the most common initial symptoms.
D. Thirst may be a side effect of lithium due to nephrogenic diabetes insipidus, and nystagmus can occur in severe neurotoxicity, but these are not the classic early warning signs.
Correct Answer is A
Explanation
Rationale:
A. A lithium serum level between 0.6 and 1.2 mEq/L is generally considered within the therapeutic range for maintenance treatment.
B. Above therapeutic limits would typically be >1.5 mEq/L, which increases toxicity risk.
C. While timing of blood draw is important, an 8-hour interval is acceptable for monitoring lithium levels (usually drawn 12 hours post-dose but 8 hours is still interpretable).
D. A level of 1 mEq/L is not below therapeutic limits.
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