A client with Ankylosing Spondylitis is curious about the disease's pathophysiology.
What explanation by the nurse is correct?
"The inflammation in Ankylosing Spondylitis primarily occurs in the peripheral joints.”
"Immune cells infiltrate muscles, leading to muscle wasting in Ankylosing Spondylitis.”
"Pro-inflammatory cytokines like TNF-α and IL-17 contribute to inflammation in Ankylosing Spondylitis.”
"The chronic inflammation in Ankylosing Spondylitis causes cartilage regeneration.”
The Correct Answer is C
Choice A rationale:
"The inflammation in Ankylosing Spondylitis primarily occurs in the peripheral joints." Rationale: This statement is incorrect.
Ankylosing Spondylitis primarily affects the axial skeleton, including the spine and sacroiliac joints.
Peripheral joint involvement is less common and usually occurs in the later stages of the disease.
Choice B rationale:
"Immune cells infiltrate muscles, leading to muscle wasting in Ankylosing Spondylitis." Rationale: This statement is not accurate.
Ankylosing Spondylitis primarily involves inflammation of the spine and sacroiliac joints, rather than muscle tissue.
Muscle wasting is not a characteristic feature of AS.
Choice C rationale:
"Pro-inflammatory cytokines like TNF-α and IL-17 contribute to inflammation in Ankylosing Spondylitis." Rationale: This statement is correct.
Ankylosing Spondylitis is associated with increased levels of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17).
These cytokines play a key role in the inflammation and tissue damage seen in AS.
Choice D rationale:
"The chronic inflammation in Ankylosing Spondylitis causes cartilage regeneration." Rationale: This statement is not accurate.
Chronic inflammation in AS can lead to structural damage and fusion of the spinal vertebrae (ankylosis), but it does not promote cartilage regeneration.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A rationale:
"Treatment typically involves surgical joint replacement." Rationale: This statement is not accurate.
While joint replacement surgery may be considered in severe cases of Ankylosing Spondylitis when joint damage is extensive, it is not a typical or first-line treatment option.
Other conservative treatments are usually attempted before considering surgery.
Choice B rationale:
"Physical therapy and exercise are crucial components of managing Ankylosing Spondylitis." Rationale: This statement is correct.
Physical therapy and exercise play a crucial role in managing Ankylosing Spondylitis.
They help improve flexibility, maintain range of motion, and strengthen the muscles supporting the spine, which can reduce pain and disability.
Choice C rationale:
"There are no effective treatments available for Ankylosing Spondylitis." Rationale: This statement is not accurate.
There are several effective treatments available for Ankylosing Spondylitis, including nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic drugs (DMARDs), biologic medications, and physical therapy.
Choice D rationale:
"Ankylosing Spondylitis is primarily managed with antibiotics." Rationale: This statement is not accurate.
Ankylosing Spondylitis is not primarily managed with antibiotics.
While bacterial infections may be associated with AS in some cases, the mainstay of treatment is focused on controlling inflammation and managing symptoms with medications and lifestyle interventions.
Correct Answer is ["A","B","D"]
Explanation
Choice A rationale:
"Limited range of motion in the spine." Rationale: Limited range of motion in the spine is a common clinical manifestation of Ankylosing Spondylitis (AS).
The inflammation and eventual fusion of the spinal vertebrae can lead to stiffness and reduced flexibility in the spine.
Choice B rationale:
"Pain and stiffness in the back and pelvis." Rationale: Pain and stiffness in the back and pelvis are hallmark symptoms of Ankylosing Spondylitis.
These symptoms are typically worse in the morning and improve with physical activity.
Choice C rationale:
"Swelling and redness in the fingers and toes." Rationale: Swelling and redness in the fingers and toes are not typical clinical manifestations of Ankylosing Spondylitis.
These symptoms are more characteristic of other rheumatic conditions, such as rheumatoid arthritis.
Choice D rationale:
"Fatigue and muscle weakness." Rationale: Fatigue and muscle weakness can be associated with Ankylosing Spondylitis, especially when the disease is active.
Chronic inflammation and pain can lead to fatigue, and muscle weakness may occur as a result of reduced physical activity.
Choice E rationale:
"Skin rashes and lesions." Rationale: Skin rashes and lesions are not common clinical manifestations of Ankylosing Spondylitis.
These symptoms are more commonly associated with other autoimmune or dermatological conditions.
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