A client with acquired immune deficiency syndrome (AIDS) and Pneumocystis jiroveci pneumonia has a CD4+ T cell count of 200 cells/mm³ (20%). The client asks the nurse why they have these recurring massive infections. Which pathophysiologic mechanism should the nurse describe in response to this client's question?

Reference Range:
T-helper CD4 cells [600 to 1500 cells/mm³ (60 to 75%)]

Choice A reason: Sodium polystyrene sulfonate is a medication that binds to excess potassium in the gastrointestinal tract and removes it from the body through feces. It is used to treat hyperkalemia, which is a high level of potassium in the blood. Hyperkalemia can cause cardiac arrhythmias and muscle weakness, and it is a common complication of AKI. Therefore, this medication should be administered first to lower the potassium level and prevent life-threatening complications.

Choice B reason: Sevelamer is a medication that binds to phosphorus in the gastrointestinal tract and removes it from the body through feces. It is used to treat hyperphosphatemia, which is a high level of phosphorus in the blood. Hyperphosphatemia can cause bone loss and soft tissue calcification, and it is a common complication of chronic kidney disease (CKD). However, it is not an urgent issue in AKI, and it does not affect the potassium level.

Choice C reason: Calcium acetate is a medication that also binds to phosphorus in the gastrointestinal tract and removes it from the body through feces. It has the same effect and indication as sevelamer, but it also provides calcium supplementation. However, it is not an urgent issue in AKI, and it does not affect the potassium level.

Choice D reason: Epoetin alfa, recombinant is a medication that stimulates the production of red blood cells in the bone marrow. It is used to treat anemia, which is a low level of hemoglobin or red blood cells in the blood. Anemia can cause fatigue, weakness, and shortness of breath, and it is a common complication of CKD and AKI. However, it is not an urgent issue in AKI, and it does not affect the potassium level.

Choice A reason: This is incorrect because monitoring pulse oximetry every 2 hours is not a sufficient or timely intervention for the nurse to implement. Pulse oximetry is a noninvasive method of measuring the oxygen saturation of hemoglobin in the blood. Normal oxygen saturation is 95% to 100%, while hypoxemia is less than 90%. However, pulse oximetry may not reflect the severity of respiratory distress or the effectiveness of nebulizer treatment in a client with asthma. Moreover, monitoring pulse oximetry every 2 hours is too infrequent for a client who is in acute respiratory distress and needs more frequent assessment and intervention.

Choice B reason: This is incorrect because teaching proper use of a rescue inhaler is not a priority or relevant intervention for the nurse to implement. A rescue inhaler is a type of short-acting bronchodilator that can be used to relieve acute asthma symptoms by relaxing the smooth muscles of the airways and improving airflow. However, teaching proper use of a rescue inhaler is not an urgent action for a client who is already receiving nebulizer treatment, which delivers a higher dose of medication directly to the lungs. Moreover, teaching proper use of a rescue inhaler is not appropriate for a client who is in respiratory distress and may not be able to focus or retain information.

Choice C reason: This is correct because elevating the head of bed to 90 degrees is the most important intervention for the nurse to implement. Elevating the head of bed to 90 degrees can help improve breathing and oxygenation by reducing pressure on the diaphragm and chest wall, increasing lung expansion and ventilation, and facilitating expectoration of mucus. This can enhance the effects of nebulizer treatment and reduce respiratory distress in a client with asthma.

Choice D reason: This is incorrect because determining exposure to asthmatic triggers is not an immediate or helpful intervention for the nurse to implement. Asthmatic triggers are substances or factors that can cause or worsen asthma symptoms by inducing inflammation or constriction of the airways. Examples of asthmatic triggers include allergens, irritants, infections, exercise, stress, or weather changes. However, determining exposure to asthmatic triggers is not a priority action for a client who is in respiratory distress and needs more urgent interventions to improve breathing and oxygenation. Moreover, determining exposure to asthmatic triggers may not change the management or outcome of an acute asthma attack that has already occurred.