A client who weighs 110 pounds receives a prescription for dalteparin 150 units/kg subcutaneously daily for 4 months. The medication is available in 7,500 units/0.3 mL prefilled syringe. How many mL should the nurse administer?

(Enter numerical value only.)

The property of the drugs that, if shared by both, indicates a need to closely monitor the client for drug toxicity is:

Highly protein bound.

When a drug is highly protein bound, it means that a significant portion of the drug molecules bind to proteins in the bloodstream. This binding can affect the availability and distribution of the drug in the body. If two drugs are highly protein bound and administered together, they may compete for binding sites on the proteins, leading to increased levels of unbound (free) drug in the bloodstream. This can result in higher drug concentrations and an increased risk of drug toxicity.

Closely monitoring the client for drug toxicity is necessary when drugs are highly protein bound because there is a potential for increased drug levels and associated adverse effects. Monitoring for signs and symptoms of drug toxicity, as well as routine laboratory tests to assess liver and kidney function, may be necessary in these cases.

The other properties listed do not necessarily indicate a need for closer monitoring for drug toxicity:

• Low bioavailability refers to the fraction of an administered dose that reaches the systemic circulation in an active form. While low bioavailability can affect the effectiveness of a drug, it does not directly imply a need for closer monitoring for drug toxicity.
• Short half-life refers to the time it takes for half of the drug concentration in the body to be eliminated. While drugs with short half-lives may require more frequent dosing, this property does not inherently suggest a need for closer monitoring for drug toxicity.
• High therapeutic index indicates a wide margin of safety for a drug, meaning that the effective dose is significantly lower than the toxic dose. A high therapeutic index implies that the drug has a wide safety margin and is less likely to cause drug toxicity.

Correct- This statement indicates a misunderstanding about the relationship between acute stress disorder (ASD) and post-traumatic stress disorder (PTSD). While both are related to traumatic events, ASD is considered an initial reaction that typically resolves within three days to four weeks, whereas PTSD involves symptoms persisting for more than a month. The nurse should provide education on the different timelines and criteria for these disorders.
Incorrect- This statement reflects a proactive approach to managing symptoms and stress through holistic methods like meditation. There's no need for follow-up teaching here.
Incorrect- This statement shows the client's recognition of the potential benefits of therapy in managing their thoughts and emotions. It indicates their willingness to engage in effective coping strategies.
Incorrect- This statement reflects an understanding that their response to the traumatic event is not uncommon and that others may have similar reactions. It's a valid perspective on shared experiences during challenging times.
Correct- The statement "This diagnosis means that I am crazy" reflects a common misconception about mental health diagnoses. The term "crazy" is stigmatizing and does not accurately represent the nature of mental health conditions. The nurse should offer reassurance that a diagnosis of ASD does not define a person's overall mental state and emphasize the importance of seeking help without judgment.
Correct- The statement "I will probably need to be on medication for the rest of my life" implies a sense of hopelessness or a narrow perspective about treatment options. While medication might be part of the treatment plan for some individuals, it's important to emphasize that treatment is personalized and can include a combination of therapies, coping strategies, and lifestyle adjustments. The nurse should encourage an open discussion about treatment goals and possibilities.