Which of the following statements about rectal drug administration is true?
Rectal drug administration delivers drugs directly to the site of action in the liver.
Rectal drug administration has a slower onset of action compared to oral administration.
Rectal drug administration can reduce systemic side effects.
Rectal drug administration is more invasive than other routes of administration.
The Correct Answer is C
Rectal drug administration delivers drugs directly to the rectum and lower colon, allowing for high local drug concentrations and reducing systemic side effects.
a. This statement is false because rectal drug administration delivers drugs directly to the rectum and lower colon, not specifically to the liver.
b. This statement may be true or false depending on the specific medication and condition being treated. Rectal drug administration can have a rapid onset of action for some conditions but may have a slower onset of action compared to oral administration for others.
d. This statement is false because rectal drug administration is non-invasive.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Acetaminophen is commonly administered rectally in the form of a suppository for the treatment of pain and fever. This route of administration allows for effective delivery of medication in patients who are unable to take medications orally.
b. Furosemide is commonly administered orally or intravenously, not rectally.
c. Metoprolol is commonly administered orally, not rectally.
d. Simvastatin is commonly administered orally, not rectally.
Correct Answer is D
Explanation
Rectal pH, the presence of stool in the rectum and blood flow to the rectum can all affect absorption of rectally administered drugs. For example, some drugs may require an acidic environment for optimal absorption and may be affected by changes in rectal pH. The presence of stool in the rectum can also affect absorption by altering contact between the drug and mucous membranes. Blood flow to the rectum can affect absorption by altering the rate at which drugs are delivered to the absorption site.
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