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Which of the following routes is affected by the first-pass effect?

A.

Oral (PO)

B.

Intravenous (IV)

C.

Intramuscular (M)

D.

Subcutaneous (SC)

Answer and Explanation

The Correct Answer is A

A.    The first-pass effect refers to the metabolism of a drug in the liver before it reaches systemic circulation. This primarily affects oral medications, as they are absorbed through the gastrointestinal tract and first pass through the liver.
B.    Intravenous (IV) drugs bypass the first-pass effect as they are directly introduced into the bloodstream.
C.    Intramuscular (IM) and D. Subcutaneous (SC) routes also bypass the first-pass effect since the drug enters the bloodstream without passing through the liver initially.
 


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Related Questions

Correct Answer is ["A","B"]

Explanation

A. Tamsulosin (Flomax): Tamsulosin is an alpha-blocker that helps relax the muscles of the prostate and bladder neck, making it easier to urinate. It is commonly used to treat BPH.
B. Finasteride (Proscar): Finasteride is a 5-alpha-reductase inhibitor that reduces the size of the prostate and is used to treat BPH.
C. Ethinyl estradiol and drospirenone (Yasmin): This is a combination oral contraceptive, not used to treat BPH.
D. Sildenafil (Viagra): Sildenafil is used to treat erectile dysfunction, not BPH.

Correct Answer is A

Explanation

A. The first-pass effect refers to the metabolism of a drug in the liver before it reaches systemic circulation. This primarily affects oral medications, as they are absorbed through the gastrointestinal tract and first pass through the liver.
B. Intravenous (IV) drugs bypass the first-pass effect as they are directly introduced into the bloodstream.
C. Intramuscular (IM) and D. Subcutaneous (SC) routes also bypass the first-pass effect since the drug enters the bloodstream without passing through the liver initially.

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