Which of the following factors can affect the absorption of rectally administered drugs?
Rectal pH
Presence of stool in the rectum
Blood flow to the rectum
All above
The Correct Answer is D
Rectal pH, the presence of stool in the rectum and blood flow to the rectum can all affect absorption of rectally administered drugs. For example, some drugs may require an acidic environment for optimal absorption and may be affected by changes in rectal pH. The presence of stool in the rectum can also affect absorption by altering contact between the drug and mucous membranes. Blood flow to the rectum can affect absorption by altering the rate at which drugs are delivered to the absorption site.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Rectal drug administration is useful for patients who are unable to take medications orally due to nausea, vomiting, or difficulty swallowing. This route of administration can reduce systemic side effects by delivering drugs directly to the rectum and lower colon. Rectal drug administration also bypasses first-pass metabolism in the liver.
Correct Answer is B
Explanation
Rectal drug administration can be messy and inconvenient to administer because it involves inserting suppositories or enemas into the rectum.
a. Rectal drug administration can have a rapid onset of action, but this is not a disadvantage.
c. The cost of rectal drug administration can vary depending on the medication used, but it is not necessarily more expensive than other routes of administration.
d. Rectal drug administration is non-invasive.
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