Which clinical manifestation of diabetes mellitus is commonly associated with weight loss despite increased appetite?

Long-standing hyperglycemia in diabetes mellitus can lead to impaired wound healing, as high blood sugar levels affect blood flow and immune function, increasing the risk of infections.

Incorrect choices:

a. This choice is incorrect. Polyuria, polydipsia, and polyphagia are the "three P's" associated with diabetes-related hyperglycemia.

b. This choice is incorrect. Nausea, vomiting, and abdominal pain are not typically related to long-standing hyperglycemia in diabetes.

c. This choice is incorrect. Blurred vision and vision loss are manifestations of diabetic retinopathy, a microvascular complication, rather than impaired wound healing.

The liver plays a central role in blood glucose regulation by releasing glucose into the bloodstream through glycogenolysis and gluconeogenesis when blood glucose levels are low. It also stores glucose as glycogen and responds to insulin and glucagon signals.

Incorrect choices:

b. This choice is incorrect. While the kidneys play a role in filtering blood and excreting waste products, they are not primarily responsible for regulating blood glucose levels.

c. This choice is incorrect. The lungs are involved in oxygen and carbon dioxide exchange and are not directly involved in blood glucose regulation.

d. This choice is incorrect. The spleen is involved in immune function and blood filtration, but it does not play a central role in blood glucose regulation.