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Where do enteric coated tablets typically disintegrate in the body?

A.

Esophagus

B.

Duodenum

C.

Stomach

D.

Colon

Answer and Explanation

The Correct Answer is B

A) Esophagus
Enteric-coated tablets are designed to not dissolve or disintegrate in the esophagus. They are coated with a protective layer that prevents the tablet from breaking down in the acidic environment of the stomach. This is to ensure that the medication is released in the part of the digestive tract where it is most needed, typically beyond the stomach.

 

B) Duodenum
Enteric-coated tablets are designed to disintegrate in the duodenum, which is the first part of the small intestine. The coating protects the tablet from stomach acid, allowing it to pass intact through the stomach and into the small intestine, where the pH is higher and the coating dissolves, releasing the medication for absorption.

 

C) Stomach
Enteric-coated tablets are specifically designed not to disintegrate in the stomach because the stomach's acidic environment could either damage the drug or cause premature release. The coating ensures that the drug is protected until it reaches the more neutral pH of the duodenum.

 

D) Colon
The colon is too far along in the digestive tract for enteric-coated tablets to typically disintegrate. The design of enteric coatings is intended to protect the drug until it reaches the duodenum, where absorption is most efficient. Enteric coatings are not meant to disintegrate in the colon.


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Related Questions

Correct Answer is A

Explanation

A) Diazepam
Diazepam (a benzodiazepine) is the first-line treatment for status epilepticus, especially in emergency situations. It works by quickly calming overactive electrical activity in the brain and can be administered intravenously for rapid effect. Diazepam is commonly given as an initial treatment due to its fast onset of action in stopping seizures.

B) Phenobarbital
Phenobarbital is an anticonvulsant that can also be used for seizures, but it is typically used in cases where seizures persist after initial treatment, or as a long-term maintenance therapy. It is not the first-line drug for status epilepticus and is typically administered after other options like diazepam have been tried.

C) Valproic acid
Valproic acid is an anticonvulsant used for chronic seizure management (like for generalized seizures and some focal seizures), but it is not typically used as the immediate treatment in status epilepticus. It may be used in the long-term management or when other drugs fail, but diazepam or lorazepam are preferred for immediate control of seizures.

D) Phenytoin
Phenytoin is another commonly used anticonvulsant, but it has a slower onset of action compared to benzodiazepines like diazepam. While phenytoin is often used for long-term seizure prevention, it is not the most immediate choice in an emergency setting. After initial seizure control with a benzodiazepine, phenytoin may be given for continued seizure prevention.

Correct Answer is B

Explanation

Given:

Ordered dose of Digoxin: 0.375 mg daily

Available Digoxin tablets: 0.25 mg/tablet

Step 1: Set up the proportion:

Desired dose (mg) / Available tablet strength (mg/tablet) = Number of tablets

Step 2: Substitute the values:

0.375 mg / 0.25 mg/tablet = Number of tablets

Step 3: Calculate the number of tablets:

Number of tablets = 0.375 mg ÷ 0.25 mg/tablet

Number of tablets = 1.5 tablets

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