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Where do enteric coated tablets typically disintegrate in the body?

A.

Esophagus

B.

Duodenum

C.

Stomach

D.

Colon

Answer and Explanation

The Correct Answer is B

A) Esophagus
Enteric-coated tablets are designed to not dissolve or disintegrate in the esophagus. They are coated with a protective layer that prevents the tablet from breaking down in the acidic environment of the stomach. This is to ensure that the medication is released in the part of the digestive tract where it is most needed, typically beyond the stomach.

 

B) Duodenum
Enteric-coated tablets are designed to disintegrate in the duodenum, which is the first part of the small intestine. The coating protects the tablet from stomach acid, allowing it to pass intact through the stomach and into the small intestine, where the pH is higher and the coating dissolves, releasing the medication for absorption.

 

C) Stomach
Enteric-coated tablets are specifically designed not to disintegrate in the stomach because the stomach's acidic environment could either damage the drug or cause premature release. The coating ensures that the drug is protected until it reaches the more neutral pH of the duodenum.

 

D) Colon
The colon is too far along in the digestive tract for enteric-coated tablets to typically disintegrate. The design of enteric coatings is intended to protect the drug until it reaches the duodenum, where absorption is most efficient. Enteric coatings are not meant to disintegrate in the colon.


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Related Questions

Correct Answer is B

Explanation

Given:

Ordered dose of amoxicillin: 30 mg/kg/day divided every 12 hours

Toddler's weight: 33 lbs

Concentration of amoxicillin suspension: 200 mg/5 mL

Step 1: Convert the toddler's weight from pounds to kilograms:

1 pound (lb) = 0.453592 kilograms (kg)

Weight in kg = 33 lbs x 0.453592 kg/lb = 14.968 kg

Step 2: Calculate the total daily dose of amoxicillin:

Total daily dose (mg) = Ordered dose (mg/kg/day) x Weight (kg)

Total daily dose (mg) = 30 mg/kg/day x 14.968 kg

Total daily dose (mg) = 449.04 mg/day

Step 3: Calculate the dose per administration:

Since the medication is given every 12 hours, there are 2 administrations per day.

Dose per administration (mg) = Total daily dose (mg) / Number of administrations per day

Dose per administration (mg) = 449.04 mg/day / 2 administrations/day

Dose per administration (mg) = 224.52 mg

Step 4: Calculate the volume to be administered:

Volume (mL) = Dose per administration (mg) / Concentration (mg/mL)

Volume (mL) = 224.52 mg / (200 mg/5 mL)

Volume (mL) = 224.52 mg x (5 mL / 200 mg)

Volume (mL) = 5.613 mL

Step 5: Round to the nearest tenth:

Volume (mL) ≈ 5.6 mL

Correct Answer is A

Explanation

Given:

Ordered dose of Dopamine: 3 mcg/kg/min

Child's weight: 41.8 lbs

Concentration of Dopamine: 400 mg in 250 mL D5W

Step 1: Convert child's weight from pounds to kilograms:

1 pound (lb) = 0.453592 kilograms (kg)

Child's weight in kg = 41.8 lbs x 0.453592 kg/lb = 18.935 kg

Step 2: Calculate the total dose of Dopamine in mcg/min:

Total dose (mcg/min) = Ordered dose (mcg/kg/min) x Child's weight (kg)

Total dose (mcg/min) = 3 mcg/kg/min x 18.935 kg

Total dose (mcg/min) = 56.805 mcg/min

Step 3: Convert mcg to mg:

Total dose (mg/min) = Total dose (mcg/min) / 1000 mcg/mg

Total dose (mg/min) = 56.805 mcg/min / 1000 mcg/mg

Total dose (mg/min) = 0.056805 mg/min

Step 4: Calculate the total dose in mg/hr:

Total dose (mg/hr) = Total dose (mg/min) x 60 min/hr

Total dose (mg/hr) = 0.056805 mg/min x 60 min/hr

Total dose (mg/hr) = 3.4083 mg/hr

Step 5: Calculate the infusion rate in mL/hr:

Infusion rate (mL/hr) = Total dose (mg/hr) / Concentration (mg/mL)

Infusion rate (mL/hr) = 3.4083 mg/hr / (400 mg/250 mL)

Infusion rate (mL/hr) = 3.4083 mg/hr x (250 mL/400 mg)

Infusion rate (mL/hr) = 2.1301875 mL/hr

Step 6: Round to the nearest tenth:

Infusion rate (mL/hr) ≈ 2.1 mL/hr

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