What term is used to describe the highest concentration of a drug in the blood after it is administered?
Peak level
Halflife
Trough level
Steady state
The Correct Answer is A
Choice A reason: Peak level is the correct term to describe the highest concentration of a drug in the blood after it is administered. Peak level is also known as peak plasma concentration or Cmax, and it reflects the rate and extent of drug absorption. Peak level is influenced by factors such as the route of administration, the dose, the formulation, and the bioavailability of the drug. Peak level is important to monitor for drugs that have a narrow therapeutic range, meaning that there is a small difference between the effective and toxic doses. The nurse should measure the peak level at the appropriate time after the drug administration, and adjust the dose or the frequency as needed to achieve the desired therapeutic effect and avoid adverse effects .
Choice B reason: Halflife is not the correct term to describe the highest concentration of a drug in the blood after it is administered. Halflife is the time it takes for the concentration of a drug in the blood to decrease by 50%. Halflife reflects the rate of drug elimination, which depends on factors such as the metabolism and excretion of the drug. Halflife is important to determine the dosing interval and the time to reach steady state. The nurse should consider the halflife of the drug when prescribing or administering the drug, and avoid drug accumulation or subtherapeutic levels .
Choice C reason: Trough level is not the correct term to describe the highest concentration of a drug in the blood after it is administered. Trough level is the lowest concentration of a drug in the blood before the next dose is given. Trough level reflects the balance between drug absorption and elimination, and it indicates the minimum effective concentration of the drug. Trough level is important to monitor for drugs that have a narrow therapeutic range, meaning that there is a small difference between the effective and toxic doses. The nurse should measure the trough level just before the next dose of the drug, and adjust the dose or the frequency as needed to achieve the desired therapeutic effect and avoid adverse effects .
Choice D reason: Steady state is not the correct term to describe the highest concentration of a drug in the blood after it is administered. Steady state is the condition when the rate of drug administration is equal to the rate of drug elimination, and the concentration of the drug in the blood remains constant. Steady state is usually reached after four to five halflives of the drug, and it reflects the optimal therapeutic level of the drug. Steady state is important to maintain for drugs that have a long halflife or a narrow therapeutic range, meaning that there is a small difference between the effective and toxic doses. The nurse should ensure that the drug is administered at regular intervals and at the appropriate dose to achieve and maintain steady state.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A reason: This is incorrect. Distributing the doses evenly throughout the day may increase the risk of daytime sedation and impair the client's ability to perform daily activities. Diphenhydramine is a sedating antihistamine that causes drowsiness and reduces alertness.
Choice B reason: This is correct. Taking most of the daily dose at bedtime may minimize daytime sedation and help the client sleep better at night. Diphenhydramine is often used as a short-term treatment for insomnia.
Choice C reason: This is incorrect. Taking the medication with meals does not affect the sedative effect of diphenhydramine. It may only reduce the risk of stomach upset, which is not a common side effect of diphenhydramine.
Choice D reason: This is incorrect. Gradually decreasing the dose once tolerance to the effect is reached may not be advisable, as it may reduce the effectiveness of the medication for relieving pruritus. Diphenhydramine is an antihistamine that blocks the action of histamine, a chemical that causes itching and inflammation in allergic reactions.
Correct Answer is ["B","C"]
Explanation
Choice A reason: This is incorrect. Polydipsia is excessive thirst, which is a symptom of hyperglycemia (high blood sugar), not hypoglycemia (low blood sugar). People with hyperglycemia lose fluid through frequent urination and become dehydrated, which makes them thirsty.
Choice B reason: This is correct. Shaking is a common sign of hypoglycemia. It occurs because the body releases adrenaline and other hormones to raise blood sugar levels. Adrenaline causes the muscles to tremble or shake.
Choice C reason: This is correct. Confusion is another common sign of hypoglycemia. It occurs because the brain does not get enough glucose, which is its main source of energy. Low blood sugar can impair cognitive functions, such as memory, attention, and judgment.
Choice D reason: This is incorrect. Tachycardia is a rapid heart rate, which can be a symptom of both hypoglycemia and hyperglycemia. However, it is not a specific or reliable indicator of low blood sugar, as it can also be caused by other factors, such as stress, anxiety, caffeine, or medication.
Choice E reason: This is incorrect. Polyuria is excessive urination, which is another symptom of hyperglycemia, not hypoglycemia. People with hyperglycemia have high levels of glucose in their blood, which draws water from the cells and increases urine output.
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