What is the primary risk factor for colon cancer?

Choice A reason: Alpha cells of the pancreas do not produce insulin. Insulin is produced by the beta cells of the pancreas. Therefore, the absence of alpha cells would not affect insulin secretion.

Choice B reason: The primary function of alpha cells in the pancreas is to produce and secrete glucagon. Glucagon is a hormone that raises blood glucose levels by promoting the conversion of glycogen to glucose in the liver. Without alpha cells, the body would not be able to secrete glucagon, leading to issues with glucose regulation.

Choice C reason: Somatostatin and gastrin are not secreted by alpha cells. Somatostatin is produced by delta cells of the pancreas and other parts of the digestive system, while gastrin is primarily produced by G cells in the stomach lining. Therefore, the absence of alpha cells would not affect the secretion of somatostatin and gastrin.

Choice D reason: Pancreatic polypeptides are produced by PP cells (pancreatic polypeptide cells) in the pancreas. The absence of alpha cells would not impact the secretion of pancreatic polypeptides.

Choice A reason: The neck is the most common site where individuals with Hodgkin Lymphoma (HL) present with nontender enlarged lymph nodes. These lymph nodes are typically firm and rubbery in texture. The cervical lymph nodes are often affected first in HL, making the neck a primary area of concern for this type of lymphoma. Early detection and biopsy of these lymph nodes can help in diagnosing HL.

Choice B reason: While the abdomen can be involved in Hodgkin Lymphoma, it is not the most common initial presentation site. Involvement of the abdominal lymph nodes typically occurs at later stages of the disease. Enlarged lymph nodes in the abdomen can be detected through imaging studies but are less accessible for physical examination compared to those in the neck.

Choice C reason: The kidney is not a typical site for lymph node involvement in Hodgkin Lymphoma. HL primarily affects the lymphatic system, including lymph nodes, spleen, and other lymphoid tissues. Direct involvement of the kidney is rare and usually occurs in advanced stages of the disease.

Choice D reason: The spleen is a lymphoid organ that can be involved in Hodgkin Lymphoma, especially in more advanced stages. However, it is not the primary site where nontender enlarged lymph nodes are first detected. Enlargement of the spleen (splenomegaly) can occur due to the spread of HL, but the initial presentation is usually in the lymph nodes of the neck.